摘要
目的:探讨针刺联合通窍鼻炎颗粒对过敏性鼻炎的临床疗效。方法:选取符合纳入标准的过敏性鼻炎患者104例为研究对象,依据随机数表法将其分为观察组与对照组,每组52例。对照组采用常规西药治疗,观察组在对照组的基础上采用通窍鼻炎颗粒联合针刺进行治疗,1周为1个疗程,两组患者均连续治疗8个疗程。比较两组患者鼻部症状及体征改善情况、治疗前后鼻部功能及血清炎性因子水平及治疗过程中不良反应发生情况。结果:与治疗前相比,治疗后两组患者鼻部鼻塞、鼻痒、流涕、喷嚏等鼻部症状及中鼻甲黏膜息肉样变或形成息肉、下鼻甲与鼻底或鼻中隔紧靠等鼻部体征积分均显著下降(P<0.01),且观察组改善程度优于对照组(P<0.05或P<0.01)。与治疗前相比,治疗后两组患者鼻腔通气功能显著增强,鼻黏膜纤毛运动速率与PEF显著加快,且观察组显著优于对照组(P<0.01)。两组患者治疗后鼻腔总阻力与PEF昼夜变异率均显著下降(P<0.01),且观察组显著低于对照组(P<0.05或P<0.01)。与治疗前相比,治疗后两组患者血清IL-4、TNF-α水平均显著下降,且观察组显著低于对照组(P<0.01)。与治疗前相比,治疗后两组患者血清IL-12水平均显著升高,且观察组显著高于对照组(P<0.01)。两组治疗过程中均未发生皮疹、咳嗽、头痛、头晕、腹泻及困倦等不良反应。结论:针刺联合通窍鼻炎颗粒治疗过敏性鼻炎可有效改善患者鼻部症状及体征,在促进鼻部功能恢复的同时抑制炎症反应,有助于患者预后。
Abstract：Objective： To investigate the clinical effect of acupuncture combined with Tongqiao Biyan Granuletreating allergic rhinitis. Methods： 104 cases of allergic rhinitis were randomly divided into the observationgroup（n = 52） and the control group（n = 52）. The control group was treated with conventional western medicine, on which basis, the observation group was also treated with Tongqiao Biyan Granule combined with acupuncture. One week was taken as one treatment course, and the treatment was eight continuous courses. Improvement of nasal symptoms and signs, nasal function, and serum levels of inflammatory factors were compared before and after the treatment in the two groups. Results： Nasal symptom scores, such as nasal congestion, itching, runny nose, and sneezing, as well as nasal sign scores, such as polypoid degeneration or formation of polyps in the mucosa of the middle turbinate and the inferior turbinate were significantly decreased afterthe treatment in the two groups（P 〈 0. 01）, the improvements of the observation group was superior to that ofthe control group（ 〈 0 05, 〈 0. 01）. Nasal ventilation function was significantly enhanced, and rates of ciliary movement of nasal mucosa and PEF were significantly accelerated after the treatment in the two groups,of which the observation group was superior to the control group（P 〈 0. 01）. The total nasal resistance and thevariation of PEF from daytime to nighttime were significantly decreased after the treatment in the two groups（P 〈 0. 01）, of which the observation group was superior to the control group（P 〈 0. 05,P 〈 0. 01）. Serumlevels of IL - 4 and TNF - α decreased significantly after the treatment in the two groups, it was significantlylower in the observation group than it was in the control group（P 〈 0. 01）. Serum level of IL - 12 increasedsignificantly after the treatment in the two groups, it was significantly higher in the observation group than itwas in the control group（P 〈 0. 01）. T
作者
张珂
ZHANG Ke(Anyang People＇ s Hospital,Anyang 455000,Chin)
出处
《中医药信息》
2018年第3期94-97,共4页
Information on Traditional Chinese Medicine
关键词
过敏性鼻炎
针刺
通窍鼻炎颗粒
炎性因子
Allergic rhinitis
Acupuncture
Tongqiao Biyan Granule
Inflammatory factor
