摘要
目的分析大理州白族和汉族不孕症患者的细胞遗传学情况是否存在差异。方法对956例不孕症患者(其中白族382例,汉族574例)的外周血淋巴细胞进行G显带染色体核型分析。结果所有不孕症患者中共发现68例染色体异常者,检出率为7.13%,其中白族染色体异常者24例,占白族患者的6.28%,汉族异常者44例,占汉族患者的7.67%,且白族和汉族染色体异常的发生率及异常染色体核型分布差异均无统计学意义(P>0.05)。结论大理白族自治州白族和汉族不孕症患者的细胞遗传学检查结果无差异。从优生优育角度考虑,论何种民族,何种生活条件,是自然妊娠还是存在不孕情况,都应在备孕或妊娠早期进行细胞遗传学检查,以防不良妊娠结局。
Objective To analyze whether there is a difference in cytogenetic between infertility patients of Bai and Han nationality in Dali. Methods G-band karyotype analysis was carry on peripheral blood lymphocytes in 956 patients with infertility （382 in Bai and 574 in Han）. Results The total number of infertile patients which carried abnormal chromosomes were 68, the detection rate was 7.13%. Among them, 24 patients of Bai had abnormal chromosomes, accounting for 6.28% of the Bai part, and 44 patients of Han had abnormal chromosomes, accounting for 7.67% of the Han part. There was no significant difference in the rate of chromosome abnormalities and abnormal karyotype distribution between the Bai and Han patients （P〉0.05）. Conclusion There was no difference in the cytogenetic results between the Bai and Han infertile patients in Dali Bai Autonomous Prefecture.From the perspective of healthy pregnancy, no matter in what nationalities or what kind of living conditions, natural pregnancy or infertility, should we do cytogenetic examination during the preparation of pregnancy or in the early time of pregnancy to prevent adverse pregnancy outcomes
作者
柴蓓蓓
何培
王惠莹
刘浏
张若鹏
Chai Beibei;He Pei;Wang Huiying(College of Clinical Medicine,Dali University;Department of Reproductive Medicine,The First Affiliated Hospital of Dali University,Dali,Yunnan 671000,China)
出处
《云南医药》
CAS
2018年第4期289-291,共3页
Medicine and Pharmacy of Yunnan
基金
云南省高校联合项目(2017FH001-078)
大理大学博士科研启动费项目(KYBS201612)
大理大学第八批中青年学术带头人培养对象项目(理大研发[2017]2号)
大理大学第一附属医院第二批院级重点学(专)科建设项目(大附院[2016]46号)
关键词
染色体多态性
染色体异常
不孕症
Chromosome polymorphism
Chromosomal abnormality
Infertility
