摘要
目的探究P504s、P63、PSMA及Ck34βE12在前列腺良恶性病变鉴别中的意义。方法选取2014年1月—2016年12月收治的直肠B超引导下的手术切除标本112例作为研究对象,所获标本均进行石蜡切片,检测切片中P504S、P63、PSMA及Ck34βE12,根据阳性细胞比例分级。对单独和联合检测P504S、P63、PSMA及Ck34βE12诊断前列腺癌的准确度,灵敏性及特异性进行统计。结果 P504S在Pca患者中阳性率为100.00%,弥散阳性率高达62.75%,显著高于AAH、BCH和BPH的表达量;P63和Ck34βE12在Pca的阳性率为0%,而在HGPIN、AAH、BCH和BPH中的表达量均为100.00%;PSM A在Pca、HGPIN的阳性率为98.04%和90.91%,在AAH、BCH和BPH中的阳性率分别为13.33%、11.11%和9.52%;P504S、P63、PSM A及Ck34βE12联合检测对前列腺癌诊断的准确度,灵敏性及特异性分别达到100.00%、97.85%和98.24%,具有一定的临床诊断价值。结论对于前列腺癌的诊断,P504S、P63、PSMA及Ck34βE12联合检测能够显著增加对前列腺癌诊断的准确度,特异性和灵敏度。
Objective To explore the significance of P504s,P63,PSMA,and Ck34βE12 in the identification of benign and malignant prostate lesions. Methods A total of 112 surgical resection specimens of transrectal ultrasound guided prostate biopsy were collected from the Traditional Chinese Medicine Hospital of Heze City of Shandong Province from January 2014 to December 2016. All specimens were prepared for paraffin section and detected for P504s,P63,PSMA,and Ck34βE12. According to the proportion of positive cells,the detection results were classified as follows. The accuracy,sensitivity,and specificity of P504 S,P63,PSMA,and Ck34βE12 detected separately and jointly in the diagnosis of prostate cancer were compared. Results The positive rate of P504s in prostate cancer patients was 100. 00%,and the dispersion positive rate was up to 62. 75%,significantly higher than those in the AAH,BCH,and BPH patients. The positive rates of P63 and Ck34βE12 in prostate cancer patients were both 0%,while those in the HGPIN,AAH,BCH,and BPH patients were all 100. 00%. The positive rates of PSMA in prostate cancer and HGPIN patients were 98. 04% and 90. 91%,respectively,while those in the AAH,BCH,and BPH patients were 13. 33%,11. 11%,and 9. 52%,respectively. The accuracy,sensitivity,and specificity of combined detection of P504s,P63,PSMA,and Ck34 reached 100. 00%,97. 85%,and 98. 24%,respectively,showing clinical diagnostic value.Conclusion For the diagnosis of prostate cancer,combined detection of P504s,P63,PSMA,and Ck34βE12 could significantly increase the accuracy,sensitivity,and specificity.
作者
李国成
LI Guocheng(Department of Surges, Traditional Chinese Medicine Hospital of Heze City of Shandong Province, Heze 274000, Chin)
出处
《外科研究与新技术》
2018年第2期93-96,共4页
Surgical Research and New Technique
