摘要
目的比较完全血运重建(CR)与非完全血运重建(IR)对冠状动脉多支血管病变(MVD)患者的长期疗效。方法 578例接受药物洗脱支架植入的MVD患者根据血运重建方案分为CR组(387例)与ICR组(191例)。比较两组患者长期随访期间主要不良心血管事件的发生率,分析CR与IR对MVD患者预后的影响。结果与IR组比较,CR组心因性死亡、非致命性心肌梗死、支架内血栓形成、靶病变血运重建、靶血管血运重建及非靶血管血运重建的事件率显著减低,差异均有统计学意义(均P<0.05);多因素Cox回归分析显示,CR可显著减少MACE、靶病变血运重建、靶血管血运重建及非靶血管血运重建事件的发生率(均P<0.05)。结论冠状动脉CR有利于改善MVD患者的长期预后。
Objective To compare long-term clinical efficacy of complete revascularization（CR）versus incomplete revascularization （IR）of coronary arteries in patients with multi-vessel disease （MVD）. Methods 578 MVD patients underwent drug-eluting stents implantation were divided into CR group （n=387）and IR group （n=191）based on revascularization strategy. Major adverse cardiovascular events （MACE） during long-term follow-up were compared between the twe groups. The influence of CR and ICR on the prognosis of patietns with MVD were analyzed. Results
The incidences of cardiac death, non-fatal myocardial infarction, in-stent thrombosis, target lesion revascularization,target vessel revascularization and non-target vessel revascularization were significantly lower in CR group than ICR group （all P〈0.05）. Multivariate Cox regression analyses showed that CR reduced the risks of MACE, target lesion revascularization, target vessel revascularization and non-target vessel revascularization（all P〈0.05）. Conclusion CR may improve the prognosis of patients with multi-vessel disease.
作者
徐肖磊
周逸蒋
王启闻
蒋鎏骏
张力
朱建华
XU Xiaolei;ZHOU Yijiang;WANG Qiwen(Department of Cardiology,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)
出处
《心电与循环》
2018年第4期237-244,共8页
Journal of Electrocardiology and Circulation
基金
国家自然科学基金(81400224)
中国心血管健康联盟-心脏康复与代谢治疗研究基金(CCA-CRMT-1614)
关键词
冠心病
介入治疗
完全血运重建
Coronary artery disease
Percutaneous coronary intervention
Complete revascularization
