摘要
目的描述北京市儿童丙型肝炎病毒(HCV)抗体阳性检出率以及HCV抗体阳性儿童的复查情况。方法选取2013-09-01—2015-08-30到北京市首都儿科研究所附属儿童医院门诊或住院连续就诊,并行HCV抗体检查的18岁以下儿童为调查对象,采用电子病历数据库方式收集调查对象人口学、诊断及HCV抗体检查结果;并对HCV抗体阳性或检查结果灰区的住院儿童用电话随访的方式询问其监护人对检查结果的知晓和复查情况。结果 25 748例就诊儿童的中位年龄2.9(1.3,6.1)岁,98%的患者因手术前、内镜前常规检查或输血而检测HCV抗体。HCV抗体阳性率为0.04%,其中因内镜检查或输血检查者抗体阳性率均为0.08%,高于因手术检查者;对HCV抗体阳性/灰区的51例住院患儿的调查发现,仅58.8%家长知晓孩子HCV抗体筛查结果为阳性或灰区,进行了HCV抗体复查的患儿占41.2%。结论北京地区儿童HCV感染呈较低水平,医生及患儿家长对HCV抗体筛查的重要性认知仍需加强。
Objective To describe the positive rate of anti-hepatitis C virus（ HCV） among children in Beijing and explore the status of anti-HCV re-examination for anti-HCV positive children. Methods P atients under 18 who had visited the Children＇s Hospital Affiliated to Capital Institute of P ediatrics from September 1 st in 2013 to August 30 th in 2015 and had tested the anti-HCV were selected as target population to collect the demographic characteristics,the diagnostic information,and the results of anti-HCV tests. For anti-HCV positive hospitalized children,telephone interviews were conducted with guardians to inquire whether the parents know their children＇s results of anti-HCV and whether the children had reexamined the anti-HCV. Results A total of 25 748 children with a median age of 2. 9（ 1. 3,6. 1） were selected and the positive rate of anti-HCV was 0. 04%. Among the HCV screened children,98% were tested anti-HCV on account of routine examination before operation,routine examination before endoscopy or blood transfusion/administration of blood product. The positive rates of anti-HCV among anti-HCV screened children on account of routine examination before endoscopy or blood transfusion/administration of blood product were both 0. 08% that is higher than that of routine examination before operation. Through the telephone interview with 51 anti-HCV grey/positive children＇s guardians,only 58. 8% parents knew their children＇s results of HCV test. 41. 2% anti-HCV positive children reexamined anti-HCV. Conclusions The infection rate of HCV among children in Beijing is low. The awareness of anti-HCV screening for parents and physicians need to be strengthened.
作者
孙园园
程凯亮
杨健
邓莉
刘艳
王丽
段钟平
SUN Yuan-yuan;CHENG Kai-liang;YANG Jian;DENG Li;LIU Yan;WANG Li;DUAN Zhong-ping(Institute of Basic Medical Sciences CAMS,School of Basic Medicine PUMC,Beijing 100005;Children＇s Hospital Capital Institute of Pediatrics,Beijing 100020;Beijing You＇an Hospital,Capital Medical University,Beijing 100069,China)
出处
《基础医学与临床》
CSCD
2018年第8期1111-1114,共4页
Basic and Clinical Medicine
基金
百时美施贵宝基金会项目(LDWJPMF-107-2014001)
关键词
丙型肝炎病毒
儿童
筛查
hepatitis C virus
children
screening
