摘要
目的探讨盐酸吗啡缓释片对癌痛患者的治疗的意义。方法收集该院2014年6月—2017年10月使用盐酸吗啡缓释片控制癌性疼痛病例64例,探讨盐酸吗啡缓释片治疗疗效、爆发痛情况、药物不良反应情况。结果该组病例包括多种病理类型恶性肿瘤,以肺癌多见;盐酸吗啡缓释片用量以日剂量60~180mg为主;治疗前平均疼痛强度评分(numeric rating scales,NRS)为(5.63±1.18)分,治疗后平均NRS评分为(1.64±0.63)分,治疗后平均NRS评分明显低于治疗前,差异有统计学意义(t=21.127,P<0.05);该组病例出现爆发痛的有32例(50.00%),其中<3次的29例(45.31%),≥3次的有3例(4.69%);出现药物不良反应的有35例(54.68%),其中出现便秘的病例有14例(21.88%)出现恶心、呕吐的病例有13例(20.31%),出现恶心、呕吐合并便秘的患者为7例(10.94%),呼吸抑制及意识障碍病例1例(1.56%),该组患者均无成瘾性不良反应发生。盐酸吗啡剂缓释片日剂量≥300 mg的病例有10例(15.63%),其中发生爆发痛病例有7例,次数<3次的6例,≥3次的有1例;有5例出现药物不良反应作用,其中便秘3例,恶心、呕吐1例,头晕、嗜睡1例。结论盐酸吗啡缓释片能有效的控制癌性疼痛,药物不良反应少,成瘾性小,临床值得推广。
Objective To study the clinical significance of morphine hydrochloride sustained-release tablets in treatment of patients with cancer pains. Methods 64 cases of patients with cancer pains treated with morphine hydrochloride sustained-release tablets in our hospital from June 2014 to October 2017 were selected, and the treatment curative effect, breakthrough pain and adverse reactions of drugs were studied. Results There were multiple types of malignant tumors, lung cancer in common; the dosage of morphine hydrochloride sustained-release tablets was 60 to 180 mg mainly; before treatment, the average numeric rating scales before and after treatment were respectively（5.63 ±1.18）points and（1.64±0.63）points, and the difference was statistically significant（t=21.127,P〈0.05）; there were 32（50.00%）cases with breakthrough pains, 29 cases whose breakthrough pains 3（45.31%）,3 cases whose breakthrough pains ≥3（4.69%）,Appearance of 35 cases of adverse drug reactions（54.68%）, including cases of constipation in 14 cases（21.88%）, nausea, vomiting, cases of 13 cases（20.31%）, nausea, vomiting, constipation combined for 7 cases（10.94%）,respiratory depression cases and disturbance of consciousness in 1 case（1.56%）, the group patients had no addiction adverse reactions occur. there were 10 cases whose daily dosage of morphine hydrochloride sustained-release tablets ≥300 mg（15.63%）, 7 cases with breakthrough pain, 6 cases whose time 3, 1 case whose time ≥3,5 cases with adverse reactions of drugs, including 3 cases with constipation, 1 case with vomiting and nausea and 1 case with headache.Conclusion The morphine hydrochloride sustained-release tablets can effectively control the cancer pains, with adverse reactions of drugs and small addiction, and it is worth clinical promotion.
作者
刘艳
顾德双
LIU Yan;GU De-shuang(Department of Tumor Medicine,Qujing Second People＇ s Hospital,Qujing,Yunnan Province,655000 China)
出处
《系统医学》
2018年第5期138-140,共3页
Systems Medicine
关键词
盐酸吗啡缓释片
癌痛患者
疼痛强度评分
爆发痛
药物不良反应
Morphine hydroehloride sustained-release tablets
Patients with cancer pains
Numeric rating scales
Breakthrough pain
Adverse reactions of drugs
