摘要
目的探讨特殊人群中碳青霉烯类抗菌药物与丙戊酸钠的相互作用及可能的作用机制,为临床医师合理使用药物提供参考。方法检索1990—2017年国内外期刊中肝肾功能不全患者和儿童患者中碳青霉烯类抗菌药物与丙戊酸钠相互作用的病例报道,以及此种相互作用的机制研究。结果肝功能不全患者中未观察到此类药物相互作用;肾脏疾病是此种药物相互作用的独立危险因素;在所有报道儿童患者中,此相互作用非常明显。结论临床中应高度警惕碳青霉烯类抗菌药物与丙戊酸钠药物相互作用,尤其在特殊生理病理状态下,应用时应避免两者合用;若两者需要联合使用时,应密切监测丙戊酸钠的血药浓度。
Objective To discuss the interaction between carbapenems and sodium valproate among special populations and the possible mechanisms,and provide references to medical treatment for clinicians. Methods Articles on interaction between carbapenems and sodium valproate among patients with liver dysfunction,patients with kidney insufficiency and children from 1990 to 2017 were selected from the electronic databases. Results Drug interaction was not observed in patients with liver dysfunction. Kidney disease was an independent risk factor for this drug interaction; The interaction between carbapenems and sodium valproate resulted in a dramatic decrease of valproate acid concentrations in children. Conclusion More attention should be paid to the serious drug interaction between carbapenems and sodium valproate,especially under special physiological and pathological conditions. The plasma concentrations of sodium valproate should be monitored when both drugs are used.
作者
万仁圣
刘晓琰
WAN Rensheng;LIU Xiaoyan(Department of Pharmacy,Renji Hospital,College of Medicine,Shanghai Jiaotong University,Shanghai 200127,China)
出处
《医药导报》
CAS
北大核心
2018年第8期1009-1011,共3页
Herald of Medicine
基金
复旦大学医院管理研究所科研课题(FDCDM201309)
