摘要
目的系统评价达克罗宁与利多卡因用于胃镜检查前准备的效果。方法计算机检索PubMed、CNKI、CBM、VIP和WanFang Data数据库,搜集比较达克罗宁与利多卡因在胃镜检查前准备效果的随机对照试验(RCT),检索时限均从建库至2017年12月31日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果共纳入11个RCT。Meta分析结果显示:达克罗宁组插管麻醉效果[RR=1.38,95%CI(1.31,1.47),P<0.000 01]和祛泡效果[RR=1.40,95%CI(1.28,1.52),P<0.000 01]均优于利多卡因组,且达克罗宁较利多卡因口味更佳[RR=1.43,95%CI(1.18,1.74),P=0.000 3]。结论达克罗宁可改善患者胃镜插管麻醉效果和祛泡效果,可作为胃镜检查前优选的准备药物。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。
Objectives To systematically review the efficacy of dyclonine and lidocaine for preparation before gastroscopy. Methods PubMed, CNKI, CBM, VIP and WanFang Data databases were electronically searched to collect randomized controlled trials（RCTs） of dyclonine vs. lidocaine for preparation before gastroscopy from inception to December 31st, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta-analysis was then performed by using Rev Man 5.3 software. Results A total of 11 RCTs were included. The results of meta-analysis showed that： dyclonine could improve anesthetic effect（RR=1.38, 95%CI 1.31 to 1.47, P〈0.000 01）, and was more capable to remove bubble（RR=1.40, 95%CI 1.28 to 1.52, P〈0.000 01）, and had superior textures（RR=1.43, 95%CI 1.18 to 1.74, P=0.000 3）. Conclusions Oral dyclonine can improve the visual definition of gastric mucosa and anesthetic effect, and has superior textures. Thus, dyclonine can be regarded as a recommended option prior to gastroscopy. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.
作者
田旭
刘晓玲
陈慧
皮远萍
陈伟庆
TIAN Xu;LIU Xiaoling;CHEN Hui;PI Yuanping;CHEN Weiqing(Key Laboratory for Biorheological Science and Technology of Ministry of Education（Chongqing University）,Chongqing Cancer Institute ＆ Chongqing Cancer Hospitol,Chongqing University Cancer Hospital,Chongqing,400044,P.R.China;Editorial Office,TMR Integrative Nursing,TMR Publishing Group,Tianjin,300210,P.R.China;Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing Cancer Institute ＆ Chongqing Cancer Hospital,Chongqing University Cancer Hospital,Chongqing,400030,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2018年第7期693-699,共7页
Chinese Journal of Evidence-based Medicine
基金
重庆大学附属肿瘤医院/重庆市肿瘤研究所/重庆市肿瘤医院临床研究基金项目(编号：LY201704)
