摘要
目的探讨术前血小板/淋巴细胞比值(PLR)在胃间质瘤(GST)患者预后评估中的作用。方法回顾性分析了92例GST患者的临床病例资料。收集所有GST患者术前3天血常规PLR数值及其病理切片中免疫组织化学检测结果。根据术前外周血PLR分为低PLR组(PLR<130,38例)和高PLR组(PLR≥130,54例),比较两组GST患者的生存情况,分析临床病理因素与术后无瘤生存率、总生存率之间的关系。结果术前PLR与GST临床病理特征中的核分裂相有关(χ~2=5.95,P=0.015)。术前高PLR组患者的无瘤生存率明显低于术前低PLR组,差异有统计学意义(χ~2=6.17,P=0.018)。单因素分析结果显示,术前PLR、术后是否接受伊马替尼治疗、美国国立卫生研究院(NIH)的肿瘤恶性潜能分级、肿瘤大小、肿瘤核分裂相与GST的术后无瘤生存率相关(P<0.05)。多因素分析结果发现,术前PLR是GST术后无瘤生存率的独立预后因素(P<0.05)。结论术前PLR可作为GST的独立预后因素。术前高PLR可能提示GST患者预后不良。
Objective To assess whether preoperative platelet-lymphocyte ratio（PLR） is an effective prognostic marker for gastric stromal tumor（GST） patients. Methods We retrospectively analyzed the clinical data of 92 patients with gastric stromal tumor. The PLR data of peripheral blood samples on the third day before surgery and immunohistochemistry results of all patients were collected. According to preoperative PLR, the patients were divided into low PLR group（PLR〈130, n=38） and high PLR group（PLR≥130, n=54）. The survival of GST patients was compared between two groups and the relationship of clinical pathological characteristics with overall survival and postoperative recurrence-free survival were analyzed. Results The preoperative PLR was related to mitotic figures（χ2=5.95, P=0.015）. The recurrence-free survival of the patients with high PLR was lower than that with low PLR before operation（χ2=6.17, P=0.018）. The recurrence-free survival was associated with preoperative PLR, adjuvant treatment with imatinib, NIH risk category, mitotic figures and tumor size in univariate analysis（P〈0.05）. The preoperative PLR was independent prognostic indicator for recurrence-free survival of GST patients in Cox multivariate analysis （P〈0.05）. Conclusion Preoperative PLR may be an independent prognostic factor for patients with gastric stromal tumor. High PLR before operation may indicate poor prognosis.
作者
胡根
李威
邵国益
张献
HU Gen;LI Wei;SHAO Guoyi;ZHANG Xian(Department of Gastroenterological Surgery, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin 214400, China)
出处
《肿瘤防治研究》
CAS
CSCD
2018年第7期479-482,共4页
Cancer Research on Prevention and Treatment
关键词
胃间质瘤
血小板/淋巴细胞比值
预后
Gastric stromal tumor
Platelet-lymphocyte ratio
Prognosis
