摘要
安全性毒理学评价是研究食品安全的重要手段。本文综述了与普洱茶有关的安全性毒理学评价研究,为认识普洱茶安全性提供参考。急性经口毒性实验显示普洱茶的半致死率(LD50)大于5 000 mg·kg^(-1),属于实际无毒级别;28 d或90 d经口毒性试验发现普洱生、熟茶提取物无明显不良效应的剂量分别是1 250和5 000 mg·kg^(-1)·d^(-1);遗传毒性研究表明普洱茶对原核细胞、真核细胞和生殖细胞均无致突变性;普洱茶的生殖毒性和发育毒性无效应剂量水平是700 mg·kg^(-1)·d^(-1);普洱茶对小鼠肝细胞的毒性极小或无;人体急性、亚急性毒性研究均未观察到病理改变。综上,已有安全性毒理学评价研究显示普洱茶具有较高的饮用安全性。
Toxicology assessment is an important index to evaluate food safety. To provide scientific references for the evaluation of safety of Pu-erh tea, relative studies were reviewed. The acute oral toxicity tests showed that the LD50 of Pu-erh tea was great than 5 000 mg·kg-1, which belonged to the actual non-toxic level. The no-observed-adverse-effect-levels of non-fermented and post-fermented Pu-erh tea were 1 250 mg·kg^-1·d^-1 and 5 000 mg·kg^-1·d^-1 in 28 d or 90 d administration tests. Pu-erh tea showed no mutagenicity on the primitive, authentic and reproductive cells during genetic toxicity evaluation. The no-observed-adverse-effect level of Pu-erh tea was 700 mg·kg^-1·d^-1 for both reproductive and developmental toxicities. Little or none toxicity of Pu-erh tea to mice liver cells was observed. No pathological change was observed in human acute and subacute toxicity assays. In conclusion, the toxicology assessments proved the safety of Pu-erh tea.
作者
马燕
陈立佼
吕才有
赵明
MA Yan;CHEN Lijiao;LYU Caiyou;ZHAO Ming(College of Longrun Pu-erh Tea,Yunnan Agricultural University,Kunming 650201,China)
出处
《茶叶科学》
CAS
CSCD
北大核心
2018年第3期221-226,共6页
Journal of Tea Science
基金
国家自然科学基金项目(31560221
31760225)
国家农业产业技术体系茶叶专项(CARS-19)
关键词
食品安全性
毒理学评价
普洱茶
food safety
toxicological assessment
Pu-erh tea
