摘要
目的:在医院电子信息系统的基础上应用药品不良事件(Adverse Drug Event,ADE)触发器对参芎葡萄糖注射液的不良事件进行挖掘。方法:自贵阳中医学院第一附属医院医院信息系统(Hospital Information System,HIS)抽取本院2016年7月~2017年6月期间使用过参芎葡萄糖注射液(贵州景峰注射剂有限公司生产)的住院病历1577份病历,排除不符合条件的病历后最终纳入1507份。并在美国健康促进研究所(IHI)推出的ADE触发工具的基础上筛选出14项ADE触发器对1507份患者的信息进行检测。结果:在调查的1507份住院病历中,14项触发器有13项触发器显阳性,触发器阳性频次为433次,占28.73%(433/1507),其中皮疹占比最高,109项,达25.17%(109/433)。确定药品不良事件27项,涉及26例患者,ADE检出率为1.79%(27/1507)。同时间段通过ADE自愿上报系统上报率为0.19%(3/1577),与经ADE触发器检出的ADE发生率相比有统计学差异(P=0.04)。结论:ADE触发器在医院信息系统的基础上用于参芎葡萄糖注射液的不良事件检测有一定的可行性,但仍需进一步完善。
Objective：On the basis of the hospital electronic information system, the Adverse Drug Event （ADE） trigger was used to excavate the adverse events of Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection. Methods： 14 ADE triggers proposed by Institute for Heahhcare Improvement were used to detect the information of 1507 patients who had used Shenxiong Gucose Injection from July 2016 to June 2017 in The First Affiliated Hospital of Guiyang University of Chinese Medicine. Results： In the 1507 investigated pa- tients＇ records, 13 triggers were in positive among the 14 triggers. The rigger positive frequency was 433 times, taking up 28.78% （433/1507）. Of these, rash took the highest rate, reaching 109 items, taking up 25.17% （109/433）. Identified adverse drug events took up 27 items, with 26 cases of patients involved. ADE detection rate was 1.79% （27/1507）. Voluntary reporting rate through ADE system in the same period was 0.19% （3/ 1507）. There was statistical difference between the incidence of ADE detected by ADE trigger and that of ADE by ADE trigger. Conclusion： It is feasible to use ADE triggers to detect Shenxiong Gucose Injection adverse druz events with Hospital Information System, while it still needs to be optimized.
作者
于佳
杨琴
陈鳌
罗君
YU Jia;YANG Qin;CHEN Ao;LUO Jun(The First Affiliated Hospital of Guiyang University of Chinese Medicine, Guiyang 550001, Guizhou China;Guiyang University of Chinese Medicine, Guiyang 550001, Guizhou China;Guiyang Adverse Drug Reaction Monitoring Center , Guiyang 550000, Guizhou China)
出处
《贵阳中医学院学报》
2018年第4期80-85,共6页
Journal of Guiyang University of Chinese Medicine
基金
贵州省科技计划项目
项目编号:黔科合LH字[2017]7145号
