摘要
目的：研究通腑平喘汤对老年慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）合并呼吸衰竭患者的疗效及FVC、FEV1/FVC水平的影响。方法：114例老年COPD合并呼吸衰竭患者以数字法随机分成观察组（57例）和对照组（57例）。对照组给予患者西医常规治疗,有改善通气、抗感染与祛痰平喘及营养支持与纠正紊乱水电解质,同时辅以呼吸机机械通气治疗;观察组在对照组的基础上给予患者通腑平喘汤治疗。对比两组疗效及预后情况。结果：治疗后观察组患者各症状消失时间及住院时间均显著低于对照组（均P〈0.05）；两组患者治疗后CRP、MDA均显著降低，SOD显著升高，且观察组明显优于对照组（均P〈0．05）；两组患者治疗后PaO2与SaO2及OI均显著升高，Lac显著下降，且治疗后各血气指标改善均明显优于对照组（均P〈0．05）；治疗前两组患者PEEPi与R及Cst间均无显著差异，治疗后PEEPi与R值均显著下降且观察组均明显优于对照组，两组Cst值均显著升高且观察组显著高于对照组（均P〈0．05）；治疗前两组患者FVC与FEV1及FEV1／FVC水平差异均无统计学意义，治疗后两组患者肺功能各水平值均有所升高，且观察组改善程度明显优于对照组（均P〈0．05）；两组患者治疗后各不良反应及总不良反应均无显著差异，无统计学意义（P〉0．05）。结论：通腑平喘汤对老年COPD合并呼吸衰竭患者的治疗疗效显著,同时有效改善了患者血气指数及肺功能等,安全可靠,值得临床参考。
Objective： To investigate the effect of Tongfu Pingchuan Decoction on chronic obstructive pulmonary disease and COPD in elderly patients with respiratory failure and the effects of FVC and FEV1/FVC levels. Methods： 114 cases of elderly patients with COPD complicated with respiratory failure were randomly divided into observation group（ 57 cases） and control group（ 57 cases）. The control group was given routine treatment,improving ventilation,anti infection and asthma and nutritional support and correcting the disorder of water and electrolyte,supplemented by mechanical ventilation treatment. The observation group on the basis of the control group was given Tongfu Pingchuan Decoction in the treatment of patients. We compared the effect and prognosis before and after treatment between the two groups. Results：After treatment,the observation group＇s symptoms disappeared time and hospitalization time were significantly lower than that of the control group（ P 〈0. 05）. The two groups＇ patients CRP and MDA after treatment were significantly decreased and SOD increased significantly,and the observation group＇s were significantly better than those of the control group（ P〈 0. 05）. The two groups＇ PaO2,SaO2 and OI after treatment were significantly increased and Lac decreased significantly,and the blood gas index improved significantly better than that of the control group（ P 〈0. 05）. Two groups＇ PEEPi and R and Cst of patients had no significant difference after treatment. PEEPi and R were significantly decreased in the observation group and significantly better than those of the control group. Cst values were significantly higher in the observation group and were significantly higher than that of the control group（ P 〈0. 05）. The differences between the two groups＇ FVC and FEV1 and FEV1/FVC levels before treatment were not statistically significant. The two groups＇ pulmonary function values were increased after treatment,and the observation group＇s improved significantl
作者
程茹
张明华
俞万钧
CHENG Ru;ZHANG Minghua;YU Wanjun(Chinese and Westem Medicine Department, Taizhou Hospital, Taizhou 318000, Zhejiang, China;Respiratory Medicine Department, Yinzhou Peoples＇ s Hospital, Ningbo 315000, Zhejiang, China)
出处
《中华中医药学刊》
CAS
北大核心
2018年第7期1653-1656,共4页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省卫生适宜技术成果转化项目(2013ZHB008)
