摘要
目的:探讨临床病理因素对胰腺癌手术预后的影响,为临床治疗胰腺癌提供一些帮助。方法:选取我院2005年1月至2013年1月期间72例行胰腺癌根治术的患者进行回顾性分析研究。选择9个可能对胰腺癌术后预后产生影响的临床因素,通过Cox比例风险模型对根治术后患者进行多因素分析,研究胰腺癌根治术后影响其疗效的相关因素。结果:单因素分析表明肿瘤大小、淋巴结转移、肿瘤病理分化程度对预后有影响(P<0.05),差异有统计学意义。Cox模型多因素分析结果表明淋巴结转移和肿瘤大小是影响预后的主要因素(P<0.05),差异有统计学意义。结论:淋巴结转移和肿瘤大小是胰腺癌根治术后影响预后最重要的因素。
Objective To explore the effect of clinicopathologic factors on the prognosis of pancreatic cancer,so as to provide some help for clinical treatment of pancreatic cancer. Methods A retrospective analysis was performed on 72 patients underwent pancreatic cancer resection from January 2005 to January 2013 at Dongfeng General Hospital of Hubei University of medicine. Nine clinical factors that may have an impact on postoperative prognosis of pancreatic cancer were selected and multivariate analysis was performed on the patients after radical resection by Cox proportional hazards model. The related factors affecting the curative effect after radical resection of pancreatic cancer were also investigated. Results Univariate analysis showed that tumor size,lymph node metastasis,and degree of tumor differentiation had an effect on prognosis（ P〈0.05）,and the difference was statistically significant. Multivariate analysis of Cox model showed that lymph node metastasis and tumor size were the main factors affecting prognosis（ P〈0.05） and the difference was statistically significant. Conclusions lymph node metastasis and the size of the tumor are the most important factors affecting prognosis after radical resection of pancreatic cancer.
作者
胡伟
张桢
沈丰
HU Wei;ZHANG Zhen;SHEN Feng(Department of Hepatobiliary Surgery, Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei 44200)
出处
《湖北医药学院学报》
CAS
2018年第2期144-147,共4页
Journal of Hubei University of Medicine
关键词
胰腺肿瘤
预后
临床病理学
Pancreatic neoplasms
prognosis
Clinicopathological feature
