摘要
目的探讨龙血竭散灌肠联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎的临床疗效。方法选取2015年9月—2017年10月在上海市松江区方塔中医医院接受治疗的溃疡性结肠炎患者105例为研究对象,根据用药方法不同将患者分为对照组(51例)和治疗组(54例)。对照组口服柳氮磺吡啶肠溶片,1.0 g/次,3次/d。治疗组在对照组治疗的基础上灌肠龙血竭散,1.2 g加入到生理盐水100 m L中,肠道保留时间1 h,1次/d。10 d为1个疗程,所有患者均接受4个疗程治疗,疗程间隔时间为5 d。观察两组的临床疗效,比较两组的促炎性因子水平、Sutherland指数和Baron内镜评分。结果治疗后,对照组和治疗组的内镜疗效总有效率分别为76.5%、90.7%,两组比较差异有统计学意义(P<0.05)。治疗后,对照组和治疗组的临床疗效总有效率分别为82.4%、94.4%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些促炎性因子水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组Sutherland指数和Baron内镜评分均明显下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论龙血竭散灌肠联合柳氮磺吡啶肠溶片治疗溃疡性结肠炎具有较好的临床疗效,可改善临床症状,降低促炎性因子水平,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Longxuejie Powder enema combined with Sulfasalazine Enteric-coated Tablets in treatment of ulcerative colitis. Methods Patients（105 cases） with ulcerative colitis in Songjiang District Fangta Traditional Chinese Medicine Hospital of Shanghai from September 2015 to October 2017 were randomly divided into the control group（51 cases） and the treatment group（54 cases） according to method. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 1.0 g/time, three times daily. Patients in the treatment group were enema administered with Longxuejie Powder on the basis of the control group, 1.2 g added into normal saline 100 m L, intestinal retention time for 1 h, once daily. 10 d for 1 course, patients in two groups were treated for 4 courses with treatment interval of 5 d. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and proinflammatory factor levels, Sutherland index scores, and Baron endoscopy scores in two groups were compared. Results After treatment, the endoscopic efficacies in the control and treatment groups were 76.5% and 90.7%, respectively, and there was difference between two groups（P〈0.05）. After treatment, the clinical efficacies in the control and treatment groups were 82.4% and 94.4%, respectively, and there was difference between two groups（P〈0.05）. After treatment, the levels of TNF-α, CRP, IL-1β, and IL-8 in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the proinflammatory factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, Sutherland index scores and Baron endoscopy scores in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in th
作者
王卫国
WANG Wei-guo(Songjiang District Fangta Traditional Chinese Medicine Hospital of Shanghai, Shanghai 201600, China)
出处
《现代药物与临床》
CAS
2018年第6期1419-1423,共5页
Drugs & Clinic
