摘要
【目的】探讨40岁以上人群中甲状腺结节的患病率和代谢相关指标之间的关系。【方法】选取40岁以上人群进行问卷调查;测量所有受试者身高、体质量、体脂率、腰围、血压;检测空腹血糖、胰岛素、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、促甲状腺激素(TSH)、游离甲状腺素(FT_4),计算体质量指数(BMI)以及稳态模型评估-胰岛素抵抗指数(HOMAIR);所有受试者进行甲状腺超声检查。【结果】本研究共纳入1 875例受试者(男性513人,女性1 362人),平均年龄(57.4±7.1)岁(41~113岁)。受试者甲状腺结节患病率为51.2%,女性明显高于男性(53.4%vs.45.2%,P=0.002)。高甘油三酯血症和高血压患者甲状腺结节的患病率明显高于对照组(分别为59.2%vs.49.5%,P=0.009和56.5%vs.47.8%,P<0.001)。多因素Logistic回归结果显示高血压(OR=1.405,P=0.002)、女性(OR=1.490,P=0.001)、较高年龄(OR=1.028,P<0.001)、高甘油三酯血症(OR=1.589,P=0.005)是甲状腺结节的独立危险因素。甲状腺结节的患病率随着年龄、收缩压和血TG水平的升高而增加。【结论】40岁以上人群甲状腺结节和代谢相关疾病的患病率较高。校正年龄及性别后高甘油三酯血症和高血压可能是甲状腺结节的独立危险因素,且在女性人群中表现更加突出。高甘油三酯血症和高血压可能与甲状腺结节的起病相关。
【Objective】The aim of our study is to examine nodule prevalence in a population over 40 years old in order to explore the relation between prevalence of thyroid nodules and metabolic parameters.【Methods】A total of 1875 individuals who were over 40 years of age were received the questionnaire and underwent thyroid ultrasonography examinations. Height,weight,waist circumference,blood pressure were measured.Levels of fasting blood glucose,fasting serum insulin,glycated hemoglobin,blood lipids,thyroid stimulating hormone and free T_4 were detected. Body mass index（BMI）and homeostasis model assessment-insulin resistance（HOMA-IR）were calculated.【Result】The study included a total of 1875 subjects（513 men and 1362 women）. The age of subjects were between 41 and 113 years old,and the mean age was 57.4±7.1 years old. The prevalence of thyroid nodules was 51.2%,and the prevalence of thyroid nodules in women was significantly higher than that in men（53.4% vs. 45.2%,P=0.002）. The prevalence of thyroid nodules was significantly higher in subjects with hypertriglyceridemia（59.2% vs. 49.5%,P=0.009）and hypertension（56.5% vs. 47.8%,P〈0.001）. Result of multivariate binary logistic regression revealed that hypertension（OR=1.405,P=0.002）,female sex（OR=1.490,P=0.001）,older age（OR=1.028,P〈0.001）,and hypertriglyceridemia（OR=1.589,P=0.005）were inde-pendent risk factors for thyroid nodules. The prevalence of thyroid nodules increased along with age,systolic blood pressure and serum triglyceride level.【Conclusion】The prevalence of thyroid nodules and metabolism-related diseases were high in population over 40 years old. After adjusted for age and sex,hypertriglyceridemia and hypertension were possible independent risk factors for thyroid nodules especially in women. In general,hypertriglyceridemia and hypertension might play an important role in the pathological process of thyroid nodules.
作者
陈晓韵
徐明彤
林刁珠
黎锋
任萌
吴木潮
张锦
王晓艺
严励
CHEN Xiao-yun;XU Ming-tong;LIN Diao-zhu;LI Feng;REN Meng;WU Mu-chao;ZHANG Jin;WANG Xiao-yi;YAN Li(Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China)
出处
《中山大学学报（医学版）》
CAS
CSCD
北大核心
2018年第3期369-376,共8页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家自然科学基金(81270915)
广东省科技计划项目(2014A020212114)
