摘要
目的研究早期微创碎吸术治疗高血压脑出血的近期手术效果及对炎症反应的影响。方法选取收治的高血压脑出血患者86例,采用随机数字表法将其分为对照组和观察组,每组43例。2组患者手术前均给予常规对症治疗,其中对照组患者于发病6~24 h间行微创碎吸术,观察组患者于发病6 h内行微创碎吸术。比较2组患者的手术效果、并发症发生率,同时比较手术前后各时间点的血清肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)及白细胞介素-6(IL-6)水平和生活质量指标评分。结果观察组的治疗总有效率(95.35%)明显高于对照组(79.08%)(P<0.05);手术后1周,观察组的血清TNF-α、IL-1β及IL-6水平均明显低于对照组(P<0.05),各生活质量指标评分明显高于对照组(P<0.05);观察组的肺部感染、应激性溃疡及肾功能不全等并发症发生率均明显低于对照组(P<0.05)。结论早期微创碎吸术治疗高血压脑出血的手术效果显著,可明显减轻患者炎症反应,减少手术相关并发症,促进生活质量恢复,值得在临床推广。
Objective To study the early minimally invasive surgery in the treatment of hypertensive cerebral hemorrhage surgery effects and the effects on inflammation. Methods 86 cases with hypertensive cerebral hemorrhage in our hospital were randomly divided into the control group and the observation group,43 cases in each group. Two groups of patients before surgery were treated by routine treatment,the patients in the control group in the incidence of 6 ～ 24 h received minimally invasive surgery,patients in the observation group in the incidence of 6 h was minimally invasive surgery. The surgery effect,the incidence of complications,and the tumor necrosis factor α（ TNF-α）,interleukin 1 β（ IL-1β） and interleukin-6（ IL-6） level at different time points before and after operation and the quality of life scores were compared. Results The total efficiency of observation group（ 95. 35%） was significantly higher than the control group（ 79. 08%）（ P 〈0. 05）; one weeks after surgery,the observation group of the serum levels of TNF-α,IL-1β,IL-6 were significantly lower than that of control group（ P 〈0. 05）,the quality of life index score was significantly higher than the control group（ P〈 0. 05）. The incidence of complication was significantly lower than the control group（ P 〈0. 05）. Conclusion Early minimally invasive surgery in the treatment of hypertensive cerebral hemorrhage surgery has significant effect,which can significantly reduce the patients with inflammatory reaction,reduce complications,promote the recovery of the quality of life,worthy of promotion.
作者
董玉萍
贺彬
张季
DONG Yuping;HE Bin;ZHANG Ji(Department of Neurosurgery , Ningxia Second People＇ s Hospital, Guyuan 756000, Chin)
出处
《宁夏医学杂志》
CAS
2018年第5期397-399,共3页
Ningxia Medical Journal
关键词
早期微创碎吸术
高血压脑出血
近期手术效果
炎症反应
Early minimally invasive aspiration technique
Hypertensive intracerebral hemorrhage
Recent surgical outcome
Inflammatory response
