摘要
目的:研究自主运动在小鼠行为绝望模型和母婴分离模型中的抗抑郁样作用。方法:采用小鼠强迫游泳实验和母婴分离模型,分别探究21 d的自主跑轮运动对急性应激和长期应激引起焦虑样和抑郁样行为的影响。结果:经过自主跑轮运动训练的小鼠在强迫游泳实验中的不动时间显著低于未经过自主跑轮运动训练的小鼠,表明自主运动具有抗行为绝望的作用。此外生命早期经历母婴分离应激的小鼠,在青春期进行自主跑轮运动,可逆转母婴分离应激引起的焦虑样和抑郁样行为。结论:长期自主跑轮运动在小鼠行为绝望模型和母婴分离模型中表现出抗抑郁样作用。
Objective： To investigate the antidepressant-like effects of exercise in forced swim test and maternal separation model in mice.Methods： C57BL/6 mice were used to study the effect of 21-day voluntary wheel running on the forced swim test and the maternal separation model followed by anxiety-and depression-related behavioral tests.Results： Mice exposed to voluntary wheel running showed decreased immobility time in forced swim test compared with non-exposed mice without running.Moreover,21-day voluntary wheel running also reversed the anxiety-and depression-like behaviors induced by maternal separation stress.Conclusion： The current findings suggest that voluntary wheel running can elicit potent antidepressant-like effects in forced swim test and maternal separation model in mice.
作者
张亦楠
黄英杰
朱维莉
时杰
ZHANG Yinan;HUANG Yingjie;ZHU Weili;SHI Jie(Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191;National Institute on Drug Dependence, Peking University, Beijing, 100191)
出处
《中国药物依赖性杂志》
CAS
CSCD
2018年第3期195-201,共7页
Chinese Journal of Drug Dependence
基金
国家自然科学基金面上项目(81371489)资助
关键词
自主跑轮运动
抗抑郁样作用
强迫游泳
母婴分离模型
早期应激
voluntary wheel running
antidepressant -like effect
forced swim test
maternal separation
early life stress
