摘要
目的探讨冠心病心绞痛患者在应用心血通颗粒治疗后对其血管内皮功能的影响及治疗效果的研究,为临床治疗方案提供参考依据。方法选取在2014年1月-2015年12月期间于我院心内科诊治的冠心病伴心绞痛患者的180例作为研究对象,随机分为两组,分别给予不同的治疗方式,其中对照组87例采取常规西药治疗,观察组93例在对照组治疗基础上加用心血通颗粒,以治疗6个月为观察期,采用心动超声检查患者心功能指标包括左心射血分数(LVEF)、左心室缩短分数(FS)、左室舒张末径(LVEDD);以ELISA检测法检测患者的外周血VEGF、内皮素-1(ET-1)、血栓素B2(TXB2)、血清一氧化氮(NO)等血管内皮功能指标水平的变化,同时统计患者治疗后的有效率及心脏不良反应事件发生情况。结果两组患者治疗后心功能指标均得到改善,其中观察组LVEF指标明显高于对照组,而FD和LVEDD指标低于对照组(P<0.05);观察组治疗后VEGF和血清NO水平明显高于对照组,而ET-1和TXB2水平明显低于对照组(P<0.05);观察组治疗有效率明显高于对照组(P<0.05)。结论冠心病心绞痛患者应用心血通颗粒与西医联合治疗,能够有效改善心功能,对血管内皮功能有积极的影响,且能提高临床治疗有效率,降低心脏不良事件的发生,值得临床推广使用。
Objective To investigate the effect of coronary atherosclerotic heart disease with angina pectoris on the vascular endothelial function and the therapeutic effect after treatment with Xinxuetong Granules and to provide reference for clinical treatment. Methods 180 patients with coronary atherosclerotic heart disease and angina pectoris who underwent heart surgery from January 2014 to December 2015 were chosen as the research object. They were randomly divided into two groups,and they were taken with different treatment methods. The control group of 87 patients was taken with conventional Western medicine treatment,and the observation group of 93 patients was taken with Xinxuetong Granuleson the basis of the control group. 6 months after treatment was as the observation period,the left ventricular ejection fraction（ LVEF）,left ventricular shortening score（ FS）,left ventricular end diastolic diameter（ LVEDD） were measured by cardiac echocardiography. The changes in the level of indicators peripheral blood VEGF,endothelin-1（ ET-1）,thromboxane B2（ TXB2）,serum nitric oxide（ NO） and other vascular endothelial function were tested by ELISA. The effective rate and incidence of adverse cardiac events of the patients were taken for statistics. Results（1）The cardiac function indicators of the two groups of patients after treatment were improved,and the VEF index of the observation group was significantly higher than that of the control group,while the levels of FD and LVEDD were lower than those of the control group（ P〈0. 05）.（2）The levels of VEGF and serum NO in the observation group were significantly higher than those in the control group,while the levels of ET-1 and TXB2 were significantly lower than those in the control group（ P〈0. 05）.（3） The effective rate of treatment in the observation group was（ 96. 77%） was significantly higher than that in the control group（ 88. 50%）（ P〈0. 05）. There was no statistically significant difference in the incidence of adve
作者
刘桂梅
LIU Jia - mei(Beijing Chaoyang Distreict Emergence Medical Rescue Center, Beijing 100026)
出处
《世界中西医结合杂志》
2018年第5期661-665,共5页
World Journal of Integrated Traditional and Western Medicine
关键词
冠心病
心绞痛
心血宁颗粒
血管内皮功能
临床疗效
Coronary Atherosclerotic Heart Disease
Angina Pectoris
Heart Blood Granules
Vascular Endothelial Function
Clinical Efficacy
