摘要
目的:埃索美拉唑与标准四联法治疗幽门螺杆菌(Helicobacter,Hp)阳性消化性溃疡疗效及血清炎症因子的关联性研究。方法:选取自2017年1月至2017年11月间接受治疗的Hp阳性消化性溃疡患者100例,采用单盲、随机设计试验,根据随机数字表法将研究对象分为对照组(奥美拉唑四联疗法组)和试验组(埃索美拉唑四联疗法组),观察两组患者治疗后Hp转阴率以及治疗前后血清炎症因子表达水平改变,观察试验组患者不良反应发生情况,并采用logistic回归分析试验组治疗Hp阳性消化性溃疡患者不良反应发生的危险因素。结果:对照组患者治疗后转阴率为64.0%,显著低于试验组的86.0%,差异具有统计学意义(χ~2=6.452,P<0.05);试验组患者治疗后IL-1,IL-6,IL-8,TNF-α和胃肠积分均显著优于对照组,差异具有统计学意义(P<0.05);Pearson相关性分析可知,IL-1(r=-0.351,P=0.015),IL-6(r=-0.441,P=0.000),IL-8(r=-0.211,P=0.034)和TNF-α(r=-0.550,P=0.000)均与胃肠积分呈负相关,相关性良好。两组患者不良反应发生率相比,差异无统计学意义(P<0.05);IL-1,IL-6,IL-8和TNF-α可能是埃索美拉唑四联法治疗Hp阳性消化性溃疡患者的独立危险因素,差异具有统计学意义(P<0.05)。结论:埃索美拉唑四联法能够通过有效抑制胃酸分泌而改善血清炎症因子表达,提高Hp转阴率,改善胃肠积分,但在不良反应发生率方面与奥美拉唑四联法相比并无明显差异,应通过加强Hp感染消化性溃疡患者入院时炎症因子检测合理选择治疗方案。
Objective： To study the efficacy of esomeprazole combined with standard triple therapy in treating Helicobacter（ HP） positive peptic ulcer and its relationship with serum inflammatory factors. Methods： A total of 100 patients with HP-positive peptic ulcer who were treated in our hospital from January,2017 to November,2017 were selected as the research subjects. Single-blind,randomized design study was conducted using a random number table. The patients were randomly divided into control group（ omeprazole quatruple therapy） and test group（ esomeprazole quatruple therapy）. HP negative conversion rate was observed after treatment. The changes of serum inflammatory cytokines in the two groups were observed. The incidence of adverse reactions in the test group was observed. Logistic regression analysis was used to analyze the risk factors of adverse reactions of esomeprazole quatruple therapy in HP-positive peptic ulcer patients. Results： The negative conversion rate in the control group（ 64. 0%） was significantly lower than that in the test group（ 86. 0%）（ χ~2= 6. 452,P 〈 0. 05）. The levels ofIL-1,IL-6,IL-8,TNF-α and gastrointestinal scores were significantly better than those in the control group（ P 〈0. 05）. Pearson correlation analysis showed that IL-1（ r =-0. 351,P = 0. 015）,IL-6（ r =-0. 441,P = 0. 000）,IL-8（ r =-0. 211,P = 0. 034） and TNF-α（ r =-0. 550,P = 0. 000） were negatively correlated with intestinal score. There was no significant difference in the incidence of adverse reactions between the two groups（ P 〈0. 05）. IL-1,IL-6,IL-8 and TNF-α might be the independent risk factors of patients with positive peptic ulcer（ P 〈 0. 05）. Conclusion： The esomeprazole quatruple therapy can improve the serum inflammatory cytokines expression,increase the negative conversion rate of HP and improve the gastrointestinal integration by effectively inhibiting gastric acid secretion,but there is no significant difference in the incidence of adverse reactio
作者
车章洪
曾芳
CHE Zhang-hong;ZENG Fang(Chongqing Southwest Aluminum Hospital, Chongqing 401326, China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2018年第12期1382-1386,共5页
Chinese Journal of New Drugs
