摘要
目的:分析新生儿接种乙肝疫苗效果评价及低、无应答者再免疫效果的预防。方法:选取行接种乙肝疫苗的新生儿146例,初次接种后对低、无应答者予再次接种(共3剂),对比并分析免疫效果。结果:出生于县级及以上医院、父母HBsAg阴性的免疫应答率84.62%、87.85%,较之出生于乡镇医院与父母HBsAg阳性显著更高(P<0.05);再免疫3次GMC含量、应答率83.33%,均显著高于再免疫1次(P<0.05);汉逊酵母乙型肝炎疫苗再免疫后1、3次GMC含量较之重组酵母乙型肝炎疫苗均更高(P<0.05)。结论:父母HBsAg阴性、于县级及以上医院出生的新生儿的乙肝免疫应答率高,汉逊酵母乙肝疫苗的效果更佳。
Objective：To analyze the effect of hepatitis B vaccine inoculation on newborns and the prevention analysis of the effect of re-immunization of low and non responders.Methods：146 newborns who were inoculated with hepatitis B vaccine were selected.Re-inoculation of low and non responders after the initial inoculation（a total of 3 agents）,and we compared and analyzed the immune effect.Results：The immune response rate of HBsAg of those who born in county hospitals and above,HBsAg negative parents was 84.62% and 87.85%,which was significantly higher than those born in township hospitals and their parents HBsAg positive（P〈0.05）.The content of GMC and the response rate 83.33% for 3 times of re-immunization were significantly higher than that of re-immunization for 1 time（P〈0.05）.The GMC content of hepatitis B vaccine hansenula polymorpha after 1 and 3 times were higher than the recombinant yeast hepatitis B vaccine（P〈0.05）.Conclusion：The hepatitis B immune response rate is high in HBsAg negative parents and newborns born at the county level and above.The effect of hepatitis B vaccine Hansenula polymorpha has better effect.
作者
杨淑琪
Yang Shuqi(Department of Planning Division of Immunology,Center for Disease Control and Prevention of Wulian County,Shandong Province,26230)
出处
《中国社区医师》
2018年第16期169-169,171,共2页
Chinese Community Doctors
关键词
新生儿
接种乙肝疫苗
低、无应答者
再免疫
Newborns
Vaccinated with hepatitis B
Low
non responders
Re-immunization
