摘要
目的:探讨右美托咪定对老年骨科患者术后谵妄的影响。方法:选择在某院择期接受骨科手术的86例老年患者,随机分为右美托咪定组(D组)和对照组(C组),每组各43例。D组在麻醉诱导前泵注0.5μg/kg的右美托咪定,C组则给予等量的生理盐水。记录两组患者术中一般情况,观察手术前后不同时间点心率(HR)及平均动脉压(MAP)等指标,并采用意识模糊评估法(CAM)确认患者术后谵妄情况。结果:两组患者手术时间、麻醉时间及术中出血量等一般手术情况比较差异不显著;拔管前5min及拔管后5min,D组患者HR及MAP水平显著低于C组;术后D组患者谵妄发生率及谵妄持续时间显著低于C组(P<0.05)。结论:老年骨科患者麻醉诱导前泵注右美托咪定可以降低患者谵妄发生,加快患者术后恢复,值得临床推广应用。
Objective：To investigate the effect of dexmetomidine on postoperative delirium in elderly orthopaedic patients.Methods：86 elderly patients were randomly divided into dexmetomidine group（group D）and control group（group C）,with 43 patients in each group.The group D was given 0.5 g/kg of dexmetomidine before induction of anesthesia,and the group C was administered with the same amount of saline.The general condition of patients in the two groups were recorded,the heart rate（HR）and mean arterial pressure（MAP）at different time points were observed before and after the operation,and the ICU confusion assessment method（CAM-ICU）was applied to confirm postoperative delirium.Results：There was no significant difference in operation time,anesthesia time and blood loss of the patients between the two groups;The HR and MAP levels in D group were significantly lower than that of C group at 5 min before extubation and 5 min after extubation;The incidence of postoperative delirium and duration of delirium in group D were significantly lower than those in group C（P〈0.05）.Conclusion：The use of dexmedetomidine before induction of anesthesia in elderly patients with orthopaedics surgery can reduce the incidence of delirium and help postoperative recovery,with worthy of clinical promotion and application.
作者
韩宏亮
陈英
贾秋芳
洪道先
Han Hongliang(Department of Anesthesiology, No.1I Affiliated Hospital of Henan University ,Kai feng 475001)
出处
《数理医药学杂志》
2018年第6期891-892,共2页
Journal of Mathematical Medicine
基金
开封市科技发展计划项目(编号:1603082)
关键词
右美托咪定
老年患者
骨科手术
术后谵妄
dexmetomidine
elderly patients
orthopaedics surgery
postoperative delirium
