摘要
在微波溶剂热中,三环己基氢氧化锡分别与2,6-H_2pydc和3,5-H_2pydc(H_2pydc=吡啶二甲酸)反应,合成了4个二(三环己基锡)吡啶-二甲酸酯:{[(2,6-Hpydc)SnCy_3]·MeOH}_n(1)、[(2,6-pydc)Sn_2Cy_6(H_2O)]·PhH(2)、[(3,5-pydc)Sn_2Cy_6(MeOH)]·MeOH(3)和[(3,5-pydc)Sn_2Cy_6(H_2O)]·EtOH(4)。对它们的组成和结构进行了元素分析、IR、(1H,13C和119Sn)NMR和单晶X射线衍射表征。化合物中心锡与配基原子构成畸形四、六面体构型,由于氢键作用,化合物形成二维大环网状超分子结构。初步探索了1、3对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)的增殖抑制活性,结果表明化合物具有广谱和较强的抗癌作用。
Four bis(tricyclohexyltin)pyridinedicarboxylates, {[(2,6-Hpydc)SnCy3]·Me}n(1), [(2,6-pydc)Sn2Cy6(H2O)]·Ph H(2), [(3,5-pydc)Sn2Cy6(MeOH)]·MeOH(3) and [(3,5-pydc)Sn2Cy6(H2O)]·EtOH(4), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide with 2,6-H2pydc and 3,5-H2pydc(H2pydc=pyridinedicarboxylic acid), respectively. Compounds 1-4 have been characterized by elemental, IR,(1H,13C and 119Sn) NMR and single crystal X-ray diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms. These compounds has a 2D network with macrocyclic supramolecular by the hydrogen bonding interaction of the neighboring molecule. The antitumor activity showed that compounds 1 and 3 have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro.
作者
邝代治
庾江喜
冯泳兰
朱小明
蒋伍玖
张复兴
KUANG Dai-Zhi;YU Jiang-Xi;FENG Yong-Lan;ZHU Xiao-Ming;JIANG Wu-Jiu;ZHANG Fu-Xing(Key Laboratory of Functional OrganometaLlic Materials of Hengyang Normal University, College of Hunan Province,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China)
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2018年第6期1035-1042,共8页
Chinese Journal of Inorganic Chemistry
基金
湖南省高校创新平台开放基金(No.16K011)
功能金属有机材料湖南省普通高校重点实验室开放基金(No.GN16K01)
湖南省自然科学基金(No.13JJ3112)资助项目
关键词
三环己基锡吡啶二甲酸酯
微波溶剂热合成
结构
体外抗肿瘤活性
tricyclohexyltinpyridinedicarboxylate
microwave solvothermal synthesis
structure
in vitro antitumor activity