摘要
目的:分析首发未用药强迫症患者静息态脑网络的特点及差异,探讨首发未用药强迫症患者的静息态脑功能状态。方法:对24例首发强迫症患者(强迫症组)及24例年龄、性别、受教育年限相匹配的健康志愿者(对照组)采用3.0T磁共振扫描仪行静息态脑功能磁共振成像(fMRI)检查,采用独立成分分析(ICA)法分离静息态脑网络成分并进行统计学分析,首先采用单样本t检验制作网络成分模板,再采用双样本t检验进行组间不同功能网络内异常脑区的比较;采用耶鲁-布朗强迫量表(YBOCS)、24项汉密尔顿抑郁量表(HAMD-24)、汉密尔顿焦虑量表(HAMA)等评估临床症状。结果:通过首发强迫症患者与正常对照组数据分析获得10个静息态脑网络模板,分别为前默认网络、后默认网络、背侧注意网络、突显网络、左额顶网络、右额顶网络、内侧视觉网络、外侧视觉网络、枕极视觉网络、听觉网络。静息态脑网络内功能连接分析结果显示后默认网络中双侧楔叶功能连接增强(T=3.822,P<0.05),右额顶网络中右侧顶下小叶功能连接增强(T=5.291,P<0.05),外侧视觉网络中右侧枕中回功能连接增强(T=4.614,P<0.05)。右侧额顶网络的右侧顶下小叶功能连接值与Y-BOCS总分呈负相关(r=-0.470,P<0.05)。结论:首发强迫症患者较健康志愿者存在多个静息态脑网络异常,主要表现为功能连接的增强;强迫症患者可能存在一定的认知功能代偿。
Objective：This study was performed to investigate the changes of resting-state networks of first-episode and treatment-naive patients with obsessive-compulsive disorder（OCD）by using resting-state functional magnetic resonance imaging（RS-fMRI）technology.Methods：A total of 24 patients with OCD and 24 age-sex-handedness-education matched healthy adults were scanned with RS-fMRI.Independent component analysis was employed for the data analysis.Statistical analysis was carried out on isolated components.One-sample t-test was performed to make the mask of networks components.And then two sample t-test was performed to explore the difference between OCD patients and healthy controls in functional networks.The Yale-Brown Obsessive Compulsive Scale（YBOCS）,24-item Hamilton Rating Scale for depression（HAMD-24）and Hamilton Anxiety Rating Scale（HAMA）were performed to assess the clinical symptoms.Results：Ten masks of resting-state networks were found in all groups.There was anterior default-mode network（aDMN）,posterior default-mode network（pDMN）,dorsal attention network（DAN）,salience network（SN）,left frontoparietal network（LFP）,right frontoparietal network（RFP）,lateral visual network（lVN）,medial visual network（mVN）,occipital pole visual network（pVN）and auditory network（AN）.It was found that the pDMN functional connectivity（FC）in OCD patients was higher than that of healthy controls in bilateral cuneus（T=3.8222,P〈0.05）,also the RFP FC increased in the right inferior parietal lobule（T=5.291,P〈0.05）and the lVN FC increased in right middle occipital lobule（T=4.614,P〈0.05）.There was a negative correlation between the activated right parietal lobule and Y-BOCS total score（r=-0.470,P〈0.05）.Conclusions：Some abnormal resting-state networks in first-episode and treatment-naive OCD patients were found,presenting increased functional connections.Certain cognitive function compensation might occur in those patients.
作者
刘俊宏
程敬亮
李幼辉
薛康康
陈苑
刘亚楠
王彩鸿
牛琪惠
文宝红
张勇
LIU Jun-hong,CHENG Jing-liang,LI You-hui(Department of MRI,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052 ,Chin)
出处
《放射学实践》
北大核心
2018年第5期448-453,共6页
Radiologic Practice
关键词
强迫症
磁共振成像
静息态功能磁共振成像
独立成分分析
静息态脑网络
Obsessive-compulsive disorder
Magnetic resonance imaging
Resting-state func-tional magnetic resonance imaging
Independent component analysis
Resting-state networks
