摘要
目的探讨地塞米松不同给药方式治疗分泌性中耳炎(secretory otitis media,SOM)的临床效果。方法选取60例SOM患者,根据不同给药方式分为观察组和对照组,各30例,对照组给予鼓膜穿刺鼓室内注射地塞米松治疗,观察组给予电子鼻咽喉镜下经咽鼓管内注射地塞米松治疗,比较两组临床治疗效果和不良反应发生情况。结果观察组治疗总有效率90.0%高于对照组73.3%,差异有统计学意义(P<0.05);血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)水平[(12.27±3.21)、(11.33±2.73)]低于对照组[(16.19±3.10)、(15.52±3.37)],差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05);随访1 a观察组复发率低于对照组,差异有统计学意义(P<0.05);两组患者各频率骨导阈值水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。结论电子鼻咽喉镜下经咽鼓管内注射地塞米松治疗SOM效果显著,不良反应少,复发率低,安全可靠。
Objective To explore clinical effect of the different dosing method dexamethasone for the treatment of secretory otitis media. Methods 60 patients with secretory otitis media were chosen,according to the different ways of drug delivery and were divided into observation group and control group.30 cases in control group were given tympanic membrane puncture drum indoor injection of dexamethasone treatment,the observation group was given electronic nose laryngoscope via eustachian tube injection of dexamethasone treatment. The clinical therapeutic effect and adverse reactions of the two groups were compared. Results Total effective rate of the eustachian tube injection treatment group was higher than drum indoor injection group,the difference was statistically significant（ P 〈 0. 05）. After treatment the eustachian tube injection group of TNF alpha,IL-6 inflammatory factor levels were lower than drum indoor injection group,difference had statistical significance（ P 〈 0. 05）. The incidence of adverse reactions in patients with more similar between the two groups after treatment had no statistical significance（ P 〉 0. 05）. After Following-up one year the recurrence rate of the eustachian tube injection group was lower than the drum indoor injection group. The difference was statistically significant（ P 〈 0. 05）. Conclusion Electronic nose laryngoscope via eustachian tube injection of dexamethasone in the treatment of secretory otitis media has better effect and has,less adverse reaction. The recurrence rate is low,and it is safe and reliable.
作者
娄希望
LOU Xi-wang(Department of Otolaryngology,Fugou County Hospital of Traditional Chinese Medicine,Fugou Henan 461300,Chin)
出处
《河南医学高等专科学校学报》
2018年第3期234-236,共3页
Journal of Henan Medical College
关键词
分泌性中耳炎
电子鼻咽喉镜
地塞米松
鼓膜穿刺
secretory otitis media
electronic nose throat mirror
Dexamethasone
tympanic membrane puncture
