摘要
目的监测2017年广州地区淋球菌临床分离株对7种抗生素的耐药情况,为科学、有效地选择抗生素治疗淋病提供理论依据。方法对广州地区临床分离培养的101株淋球菌,用琼脂稀释法测定青霉素、四环素、环丙沙星、大观霉素、阿奇霉素、头孢曲松、头孢克肟的最低抑菌浓度(MIC),根据世界卫生组织(WHO)的标准判定其敏感性。结果检出产青霉素酶淋球菌(PPNG)达21.43%(21/98),质粒介导的高度耐四环素淋球菌(TRNG)达24.49%(24/98),环丙沙星耐药率高达100%(98/98),阿奇霉素耐药率达6.12%(6/98),大观霉素未发现耐药菌,头孢曲松中度敏感率达6.93%(7/101),头孢克肟中度敏感率达15.84%(16/101)。结论持续进行淋球菌耐药性监测为制定合理抗菌治疗方案提供科学指导,是降低淋球菌对抗生素的耐药率的有效办法。
Objective To evaluate resistance of clinical isolates of Neisseria gonorrhoeae to sev- en antibiotics in Guangzhou area in 2017 in order to provide a rationale for scientifi- cally choosing antibiotics and effectively treating gonorrhea. Methods A total of 101 strains of Neisseria gonorrhoeae were isolated and cultured, and their sensitivity to the seven antibiotics, including penicillin, tetracycline, ciprofloxacin, spectinomycin, azithromycin, ceftriaxone, cefixime, were measured based on the minimum inhibitory concentration （MIC） determined with Agar dilution method, according to the World Health Organization （WHO） standard. Results The resistance rate of Neisseria gon- orrhoeae （PPNGs） to penicillin was 21.43 %, while gonococcal isolates with plasmid- mediated, high-level resistance to tetracycline accounted for 24. 49%. Rate of cipro- floxacin resistance was 100% ; rate of azithromycin resistance was 6. 12%, but no strain resisted to spectinomycin. Strains that were moderately sensitive to ceftriaxone and cefixime were 6.93% and 15.84%, respectively. Conclusion Continuously monitoring the drug resistance of gonococcus can guide the development of appropriate approach against microbes and reduce the resistance rate of Neisseria gonorrhoeae to anti- biotics.
作者
陈慧姮
曹文苓
薛如君
梁景耀
刘玉梅
张锡宝
CHEN Huiheng;CAO Wenling;XUE Rujun;LIANG Jingyao;LIU Yumei;ZHANG Xibao(Institute of Dermatology, Guangzhou Medical University, Guangzhou Institute of Dermatology, Guangzhou 510095, China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2018年第7期791-794,共4页
The Chinese Journal of Dermatovenereology
基金
广州市医药卫生科技项目(20171A011284)
关键词
淋球菌
最低抑菌浓度
耐药监测
PPNG
TRNG
Neisseria gonorrhoeae
Minimum inhibitory concentration
Antimicrobial resistance
PPNG
TRNG
