摘要
转化生长因子-β超家族成员在中枢神经系统发育及相关疾病的发生发展过程中发挥了重要作用．生长分化因子10（GDF10）是其中最重要的成员之一。GDF10参与小脑发育过程中的组织构建．并与神经性疼痛、脑梗死等疾病的转归密切相关。这为一系列神经系统疾病的发病机制研究及新治疗手段的开发提供了新的思路及靶点。本文围绕GDF10的生化结构，下游信号通路，及其在神经性疼痛、小脑发育和脑梗死等发生发展过程中的作用综述如下。
Recent studies have demonstrated that superfamily of transforming growth factor-β （TGF-β） plays vital roles in the development of nervous system and neurological diseases. Growth differentiation factor 10 （GDF 10） is one of the most prominent members of this superfamily. GDF 10 has been shown to participate in tissue formation during cerebellar development and be closely related to the outcomes of neuralgia, ischemic stroke and other neurological diseases. These findings provide novel ideas for research into pathogenesis of nervous system diseases and targets for development of new therapeutic approaches. This article reviews biochemical structure of GDF10, its downstream signaling pathways, and its roles in cerebellar development, neuralgia and ischemic stroke. Also the possible neurological diseases that may be treated by GDF10 are listed.
作者
李思佳
王建平
崔可飞
余列
付晓杰
Li Sijia;Wang Jianping;Cui Kefei;Yu Lie;Fu Xiaojie(Department of Neuralogy, The Fifth Affiliated Hospital to Zhengzhou University, Zhengzhou 450052, China;Department of Ultrasound, The First Affiliated Hospital to Zhengzhou University, Zhengzhou 450052, China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2018年第6期645-648,共4页
Chinese Journal of Neuromedicine
基金
国家自然科学基金（81571137）
河南省科技创新人才计划（154200510014）
河南省医学科技攻关计划项目（201501005）
关键词
生长分化因子10
小脑发育
脑梗死
神经性疼痛
Growth differentiation factor 10
Cerebellar development
Stroke
Neuralgia
