摘要
干粉吸入制剂作为医药行业近年来的研究热点,具有非常优越的应用前景,其研发生产对干粉的粉末特性具有严格的要求。药物﹑载体及添加剂的物料性质﹑环境以及处理条件则决定了各种粒子间作用力的相对大小,进而影响粉末的宏观性质。通过多种手段了解干粉的粉末特性,选择最优的处理条件﹑处方模式﹑装置设计是干粉吸入制剂研发的关键。
Dry powder inhalers（DPIs） have been one of the research hot spots in recent years, with an excellent application prospect. Research and development of DPIs have strict requirements on powder characteristics of dry powder. Properties of active pharmaceutical ingredients, carriers and additives, environment and processing conditions decide the relative strength of the inter-particle forces, then affect the macroscopic properties of the powder. Understanding the powder properties by a variety of means, selecting the optimal processing conditions and formulation patterns, device design are the keys to the research and development of DPI formulation. Recently, DPIs prepared by novel engineering technology such as Techno Sphere and Pulmo SpheresTM have been on market.
作者
朱万辉
吴闻哲
ZHU Wanhui;WU Wenzhe(National Pharmaceutical Engineering Research Center,China State Institute of Pharmaceutical lndustry, Shanghai 201203)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2018年第6期722-729,共8页
Chinese Journal of Pharmaceuticals
关键词
干粉吸入制剂
粉末特性
处方模式
综述
dry powder inhaler
powder characteristics
formulation pattern
review
