摘要
目的 调查哈尔滨市人群碘营养水平及甲状腺结节的患病情况，了解人群尿碘水平与甲状腺结节检出率的相关性。方法 2015 - 2017年，在哈尔滨市的18个社区，选择常住居民（10年以上）作为调查对象，采集所有调查对象空腹晨尿，检测尿碘含 量，同时检查甲状腺结节患病情况。尿碘检测采用砷铈催化分光光度法，甲状腺结节检查采用B超法。结果 共选择2 552例居民作 为调查对象，其中男性371例、女性2 181例，平均年龄（45.79 ± 12.06）岁。人群尿碘中位数为159.8 μg／L，不同年龄组人群 尿碘频数分布比较差异有统计学意义（χ2 = 40.097，P 〈 0.01）；不同性别尿碘中位数比较差异有统计学意义（U = 2.122，P 〈 0.05），其中男性为166.6 μg／L，女性为156.2 μg／L。人群甲状腺结节检出率为48.75%（1 244／2 552），标化率为40.55%， 不同年龄组甲状腺结节检出率比较差异有统计学意义（χ2 = 114.922，P 〈 0.01），且检出率随年龄增大而上升（χ2趋势 =111.746，P 〈 0.01）；其中男性为41.24%（153／371），标化率为41.13%，女性为50.02%（1 091／2 181），标化率为49.20%， 不同性别甲状腺结节检出率比较差异有统计学意义（χ2 = 9.790，P 〈 0.01）。碘摄取不足（尿碘值0 -＜ 100 μg／L）人群甲 状腺结节检出率为55.58%（244／439），碘适宜人群（尿碘值100 - ＜ 200 μg／L）甲状腺结节检出率为46.68%（591／1 266） 。结论 哈尔滨市人群整体处于碘营养适宜水平，人群甲状腺结节检出率较高，且随年龄增加检出率增高，女性高于男性。定期检 测尿碘并调整碘营养水平将有助于预防甲状腺结节的产生。
Objective To investigate the iodine intake level and the prevalence of thyroid nodules in Harbin City, and to study the correlation between the concentration of urinary iodine and the prevalence of thyroid nodules. Methods In Harbin, 18 communities were randomly selected and specimens were collected from fasting morning urine from 2015 to 2017. The urine iodine concentration （UIC） was detected by arsenic cerium catalytic spectrophotometry, and the thyroid nodule was examined by B ultrasound. Results A total of 2 552 residents aged （45.79 ± 12.06） years old agreed to participate in the study, including 371 males and 2 181 females. The median UIC in all participants was 159.8 μg/L, there was a significant difference in urine iodine frequency distribution among age groups （χ2 = 40.097, P 〈 0.01）. Furthermore, the median UIC in male was 166.6 μ g/L, and in female was 156.2 μg/L. There was a significant difference in UICs between male and female （U = 2.122, P 〈 0.05）. The prevalence of total thyroid nodules in all participants was 48.75% （1 244/2 552）, and the standardized rate was 40.55%. Significant difference in the detection rate of thyroid nodules was observed among age groups （χ2 = 114.922, P 〈 0.01）, and there was a positive and significant correlation between the detection rate of thyroid nodules and increasing age （χ2trand = 111.746, P 〈 0.01）. Furthermore, in male, 41.24% （153/371） had thyroid nodules, with standardized prevalence rate of 41.13%, and in female, 50.02% （1 091/2 181） had thyroid nodules, with standardized prevalence rate of 49.20%. Likewise, there was a significant difference in the detection rate of thyroid nodules between male and female（χ2 = 9.790,P 〈 0.01）. The detection rate of thyroid nodules in the iodine deficient population （urinary iodine was 0 - 〈 100 μg/L） was 55.58% （244/439）, and the incidence of thyroid nodules in the iodine adequate or optimal population （urinary iodine was 100 - 〈 200 μg/L ） was 46.68%
作者
连丽新
吴东红
齐明
郭宝帅
赵雪琦
吕文超
胡涛
李晓阳
Lian Lixin;Wu Donghong;Qi Ming;Guo Baoshuai;Zhao Xueqi;Lyu Wenchao;Hu Tao;Li Xiaoyang(Department of General Surgery, First Hospital of Harbin, Harbin 150010, China;Department of Endocrinology, First Hospital of Harbin, Harbin 150010, Chin)
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2018年第6期473-476,共4页
Chinese Journal of Endemiology
基金
哈尔滨市科技创新人才研究项目(2015RAXYJ055)
关键词
碘
尿
甲状腺结节
Iodine Urine Thyroid nodules
