摘要
目的研究不同药物联合治疗对5岁以上中度持续期哮喘患儿肺功能及儿童哮喘测试(C-ACT)的影响。方法选取2015年10月-2017年3月该院收治的5岁以上中度持续期哮喘患儿96例,采用随机数字法将其分为对照组和观察组,每组48例。对照组患儿接受辅舒酮联合顺尔宁治疗,观察组患儿接受舒利迭治疗。比较两组患儿的治疗总有效率和不良反应发生率,同时比较治疗前和治疗后4周、12周C-ACT评分、外周血嗜酸性粒细胞(EOS)计数及肺功能指标水平。结果观察组患儿治疗总有效率(87.50%)明显高于对照组(72.92%),差异有统计学意义(χ~2=4.94,P=0.02);治疗后4周和12周观察组患儿C-ACT评分均明显高于对照组(P<0.01),外周血EOS计数均明显低于对照组(P<0.01),第1秒用力呼气量(FEV1)和峰值气流速(PEF)值均明显高于对照组(P<0.01);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论吸入性糖皮质激素(ICS)联合长效β2受体激动剂(LABA)对5岁以上中度持续期哮喘患儿的哮喘症状改善明显,降低患儿外周血EOS计数水平,促进肺功能恢复。
Objective To research the effect of combined treatment of different drugs on pulmonary function and childhood asthma control test（ C-ACT） in children more than 5 years old with moderate asthma during persistent period. Methods From October 2015 to March2017,96 children more than 5 years old with moderate asthma during persistent period treated in Fengcheng Hospital of Fengxian District were selected and divided into control group and observation group according to random number table,48 children in each group. The children in control group were treated by flixotide combined with Singulair,and the children in observation group were treated by Seretide. The total effective rates and incidence rates of adverse reactions in the two groups were compared. C-ACT scores,peripheral blood eosinophils（ EOS） counts,and the levels of pulmonary function indexes were compared between before treatment and at 4,12 weeks after treatment.Results The total effective rate in observation group was 87. 50%,which was statistically significantly higher than that in control group（ 72. 92%）（ χ~2= 4. 94,P = 0. 02）. At 4 and 12 weeks after treatment,C-ACT score in observation group was statistically significantly higher than that in control group（ P〈0. 01）,peripheral blood EOS count in observation group was statistically significantly lower than that in control group（ P〈0. 01）,FEV1 and PEF in observation group were statistically significantly higher than those in control group（ P〈0. 01）,there was no statistically significant difference in the incidence rate of adverse reactions between the two groups（ P〈0. 05）.Conclusion Inhaled corticosteroids combined with long-acting β2 receptor stimulant（ LABA） can significantly improve the symptoms of asthma,reduce peripheral blood EOS count,and promote the recovery of pulmonary function in children more than 5 years old with moderate asthma during persistent period.
作者
王春燕
李恒涛
WANG Chun- Yah;LI Heng- Tao.(Department of Pediatrics, Fengcheng Hospital of Fengxian District, Shanghai, 201411 , China)
出处
《中国妇幼保健》
CAS
2018年第11期2504-2507,共4页
Maternal and Child Health Care of China
基金
上海市奉贤区科学技术委员会科学技术发展基金项目(奉科20151236)
关键词
舒利迭
辅舒酮
顺尔宁
5岁以上
中度持续期哮喘
肺功能
C-ACT
Seretide
Flixotide
Singulair
More than 5 years old
Moderate persistent asthma
Puhnonaly tunetion
C-ACT
