摘要
目的探讨稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)病人吸入支气管舒张剂后深吸气量(inspiratory capacity,IC)与运动耐量的关系。方法对42例稳定期COPD病人进行常规肺功能检测和6 min步行试验(six-minute walk test,6MWT),以6 min步行距离(6MWD)和Borg评分来评价病人的运动耐量和呼吸困难程度;病人吸入复方异丙托溴胺2.5 ml(沙丁胺醇3 mg/异丙托溴胺500μg)后复查肺功能和6MWT,探讨IC与运动耐量的关系。结果吸入复方异丙托溴胺后,第1秒用力呼气量(FEV1)、用力肺活量(FVC)、IC、残气量(RV)、功能残气量(FRC)和肺总量(TLC)及6MWD均有显著的改善,但仅IC的增加(△IC%)与6MWD的增加(△6MWD)和运动后Borg呼吸困难评分的改善(△Borg步行后)之间存在显著相关性。结论支气管舒张剂治疗后IC的增加与病人运动耐量和呼吸困难的改善密切相关。
Objective To study the association of inspiratory capacity（ IC） and exercise torlerance,after bronchodilators inhalation in patients with stable chronic obstructive pulmonary disease（ COPD）. Methods Forty-two stable COPD patients were underwent pulmonary function test and sixminute walk test（ 6 MWT） on the baseline and after salbutamol/ipratropium（ salbutamol 3 mg and ipratropium 500 μg） inhalation. Six-minute walk distance（ 6 MWD） and the score of Borg dyspnea scale was used to evaluate the exercise tolerance and the degree of dyspnea. Results After salbutamol/ipratropium（ salbutamol 3 mg and ipratropium 500 μg） inhalation,the forced expiratory volume in one second（ FEV1） 、forced vital capacity（ FVC） 、IC、residual volum（ RV） 、functional residual capacity（ FRC） 、total lung capacity（ TLC） and 6 MWD were significantly improved than those before inhalation.But only the change of IC correlated strongly with the improvement of 6 MWD and the score of Borg dyspnea. Conclusions Changing of IC after bronchodilators is associated with the improvement of exercise torlerance and exertional dyspnea.
作者
张海霞
ZHANG Hai-xia(Department of General- Medicine, Beijing Daxing Hospital, Capital Medical University, Beijing 102600, China)
出处
《实用老年医学》
CAS
2018年第5期433-435,共3页
Practical Geriatrics
关键词
深吸气量
慢性阻塞性肺疾病
支气管舒张剂
肺功能
6min步行试验
inspiratory capacity
chronic obstructive pulmonary disease
bronchodilators
lungfunction
six-minute walk test
