摘要
目的研究茵山莲颗粒联合注射用生长抑素治疗急性胰腺炎的临床疗效。方法选取2015年6月—2017年6月开滦总医院收治的急性胰腺炎患者120例为研究对象,随机将所有研究对象分为对照组和治疗组,每组各60例。对照组微量泵静脉注射注射用生长抑素,首次100μg,而后以50μg/h匀速泵入。治疗组在对照组治疗基础上口服茵山莲颗粒,2袋/次,2次/d。两组患者均连续治疗14 d。观察两组的临床疗效,比较两组的临床症状消失时间和生化指标。结果治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组呕吐、腹胀、高热、无便、上腹压痛消失时间短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组脂肪酶、血淀粉酶、白细胞数、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平显著下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组生化指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论茵山莲颗粒联合注射用生长抑素治疗急性胰腺炎具有较好的临床疗效,能改善临床症状,调节生化指标,安全性较高,具有一定的临床推广应用价值。
Objective To study the clinical effect of Yinshanlian Granules combined with Somatostatin for injection in treatment of acute pancreatitis. Methods Patients（120 cases） with acute pancreatitis in Kailuan General Hospital from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were micropump intravenous injection administered with Somatostatin for injection, first dosage 100 μg, and then 50 μg/h at uniform speed. Patients in the treatment group were po administered with Yinshanlian Granules on the basis of the control group, 2 bags/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms disappeared time and biochemical indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there was difference between two groups（P〈0.05）. After treatment, the clinical symptoms disappeared times of vomiting, abdominal distention, high fever, defecation, and upper abdominal pain in the treatment group were shorter than those in the control group, and there was difference between two groups（P〈0.05）. After treatment, the levels of lipase, blood amylase, white blood cell number, TNF-α, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Yinshanlian Granules combined with Somatostatin for injection has clinical curative effect in treatment of acute pancreatitis, can improve clinical symptoms, and regulate biochemical indexes, with good safety, which has a certain clinical application value.
作者
高建超
费乐学
GAO Jian-chao;FEI Le-xue(Department of General Surgery, Kailuan General Hospital, Tangshan 06300)
出处
《现代药物与临床》
CAS
2018年第5期1093-1096,共4页
Drugs & Clinic
