摘要
小胶质细胞是中枢神经系统中关键免疫效应细胞,激活后的小胶质细胞有M1和M2两种形态,当小胶质细胞受到过度刺激时会打破两者之间的平衡,导致过度活化,从而引起或加剧神经退行性疾病中的神经损伤。因此找到抑制活化的物质对于神经退行性疾病的治疗具有重要意义。本世纪以来,海洋源生物活性物质得到广泛运用,海洋生物已经成为药物重要来源之一,其中一些物质具有抑制小胶质细胞活化的作用。本文综述了小胶质细胞活化与神经退行性疾病之间的关系以及目前海洋源抑制小胶质细胞活化活性物质的研究状况,为进一步药物开发和机制研究提供参考。
Microglial cells, as the key players of immunization in the central nervous system, have two separate states after activation： M1 and M2. The balance can be broken when microglial cells are overstimulated, and may lead to excessive activation of the cells, causing or aggravating nerve injury in the neurodegenerative diseases. For this reason, finding substances which can inhibit the microglia activation is important in therapies for neurodegenerative diseases. This century witnesses the extensive application of marine bioactive substances, and sea creatures have become one important source of drugs. Meanwhile some of the marine bioactive substances can restrain the activation of microglial cells. This paper summarizes the connection between activated microglia and neurodegenerative diseases and the existing research situation of marine bioactive substances with inhibitory effects, and all above provides references for further exploiting and research on mechanisms in the future.
作者
徐晓萌
杨隆河
林祥志
王昭凯
XU Xiao-meng;YANG Long-he;LIN Xiang-zhi;WANG Zhao-kai(Third Institute of Oceanography, State Oceanic Administration, Xiamen Fujian 361005)
出处
《中南药学》
CAS
2018年第5期669-674,共6页
Central South Pharmacy
基金
海洋经济创新示范项目(编号:16PYY005SF09)
关键词
小胶质细胞
活化状态
神经退行性疾病
海洋源活性物质
microglial cell
activation state
neurodegenerative disease
marine bioactive substance
