摘要
强直性脊柱炎(ankylosing spondylitis,AS)发病较为隐蔽,机制复杂。目前临床诊断方法具有明显的滞后性,因此寻求更为快速、准确的早期诊断指标对缓解甚至治愈AS显得极为重要。现有的大量研究显示肠道微生物与AS关系密切,且可能通过肠道微生物与遗传因子HLA-B27相互作用、肠道通透性改变介导的肠黏膜IgA免疫应答和炎性因子的过度表达、肠-脑轴、肠道微生物之间的相互作用等机制导致AS的发生发展。本文就AS患者肠道微生物变化及肠道微生态失调与AS的相关性作一综述。
The onset of ankylosing spondylitis（AS）is concealed and complicated.The current clinical diagnosis method is obviously lack of timeliness,so it′s very important to look for a more rapid and accurate early diagnosis index in order to relieve or even cure AS.A large number of existing researches showed that the gut microbiota is closely related to AS,and may lead to the development of AS through different mechanisms such as the interaction between gut microbiota and genetic factor HLA-B27,intestinal mucosal IgA immune response and inflammatory factor overexpression mediated by intestinal permeability changes,the interaction between brain-gut axis and intestinal microbes,and so on.This article reviews the changes of intestinal microflora in patients with AS,and the possible correlation between AS and intestinal microecology.
作者
张利龙
胡雨奇
许尧
金祺
马红
袁杰利
李霞
李明
ZHANG Lilong;HU Yuqi;XU Yao;JIN Qi;MA Hong;YUAN Jieli;LI Xia;LI Ming(Dalian Medical University, Second Clinical College, Dalian, Liaoning 116044, China)
出处
《中国微生态学杂志》
CAS
CSCD
2018年第5期613-618,F0003,共7页
Chinese Journal of Microecology
基金
中国博士后科学基金(2016M601317)
辽宁省大学生创新创业项目(2017101610100031)
关键词
肠道微生物
菌群失调
强直性脊柱炎
Intestinal microflora
Intestinal dysbiosis
Ankylosing spondylitis
