摘要
本研究将栓剂基质不耐高温、阻碍药物释放及影响栓剂载药量的缺点加以改良,以高效液相色谱法测定治糜灵泡腾胶囊栓中盐酸小檗碱的含量,经正交试验考察后,最佳提取条件为6倍量60%乙醇,提取3次,每次1.5h。泡腾胶囊栓中枸橼酸与NaHCO_3最佳比例确定为1∶0.6,用量为30%。本文解决了栓剂在贮存和使用上给患者和经营商带来的不便,将极大地促进栓剂的发展和应用。
This research project improve suppositories＇ shortcomings, including the matrix is not heat-resisting, hinders releasing drug and influences drug loading. The content of berberine hydrochloride was determined by high performance liquid chromatography. After investigation by orthogonal design, the optimum extraction conditions were 6 times 60% ethanol, which was extracted 3 times for 1.5 hours. The optimum proportion of citric acid and sodium bicarbonate in the effervescent capsule suppository was 1：0.6, and the dosage was 30%. This research has solved the inconvenience caused by the suppository to the patients and operators in storage and use, and will greatly promote the development and application of suppositories.
作者
于浩然
刘磊
田振坤
吴伦
YU Hao-ran;LIU Lei;TIAN Zhen-kun;WU Lun(Heilongjiang University of Chinese Medicine, Harbin 150040, China)
出处
《化学工程师》
CAS
2018年第5期13-15,5,共4页
Chemical Engineer
基金
黑龙江中医药大学新药研究基金项目(2013xy02)
关键词
高效液相色谱法
泡腾胶囊栓
制备工艺
high performance liquid chromatography
effervescent capsules
preparation technology
