摘要
目的:探析隐性梅毒患者外周T淋巴细胞亚群对苄星青霉素G驱梅疗效的影响。方法:选择2015年5月至2016年3月在浙江省桐乡市皮肤病防治院收治的隐性梅毒病人76例为研究对象,根据临床疾病分期将其分为早期组(n=40例)和晚期组(n=36例),两组均进行苄星青霉素G驱梅治疗,随访半年,应用流式细胞仪检测两组患者治疗前后的CD4+/CD8+、CD8+、CD4+、CD3+等外周血T细胞亚群水平;比较两组患者的临床治疗效果;比较全部研究对象中有效者与无效者CD4+/CD8+、CD8+、CD4+、CD3+的外周血T淋巴细胞亚群水平的变化情况。结果:早期组患者的临床有效率为70.0%,晚期组患者的临床有效率为38.9%,两组差异具有统计学意义(P<0.05);两组患者治疗后的CD4+/CD8+、CD8+、CD4+、CD3+等外周血T淋巴细胞亚群指标水平均有升高,早期组患者的相关指标水平显著高于晚期组,两组差异具有统计学意义(P<0.05);有效者的CD4+/CD8+、CD8+、CD4+、CD3+等外周T淋巴细胞亚群水平显著高于无效者,其差异具有统计学意义(P<0.05)。结论:隐性梅毒患者的细胞免疫功能水平低下,苄星青霉素G驱梅检测患者的外周血T细胞亚群对评估患者的临床治疗效果具有重要价值。
Objective： To discuss the effect of peripheral blood T lymphocyte subpopulation of patients with latent syphilis on the syphilitic driving efficacy of Benzathine Benzylpenicillin G. Methods： 100 patients with latent syphilis admitted to Tongxiang Dermatosis Prevention and Treatment Hospital from May 2015 to March 2016 were divided into early group（ n = 54） and late group（ n = 46） according to clinical staging of disease. The two groups were treated with Benzathine Benzylpenicillin G for syphilitic driving with half a year follow-up visit. Peripheral blood T lymphocyte subpopulation levels were tested before and after the treatment by using flow cytometry instrument in terms of CD4 ＋/CD8 ＋,CD8 ＋,CD4 ＋,CD3 ＋,etc. The clinical therapeutic effects of two groups were compared. The changes in level of peripheral blood T lymphocyte subpopulation were compared between the effective and ineffective subjects in terms of CD4 ＋/CD8 ＋,CD8 ＋,CD4 ＋ and CD3 ＋. Results： The clinical effective rate of the early group and late group was 74. 1% and 43. 5%,with statistically significant difference（ P〈0. 05）. After treatment,the index level of peripheral blood T lymphocyte subpopulation were increased in terms of CD4 ＋/CD8＋,CD8 ＋,CD4 ＋,and CD3 ＋,etc. However,the post-treatment index levels of early group were significantly higher than those of late group in terms of CD4 ＋/CD8 ＋,CD8 ＋,CD4 ＋,and CD3 ＋,etc. The difference was statistically significant（ P〈0. 05）. The levels of peripheral blood T lymphocyte subpopulation in effect subjects were significantly higher than ineffective subjects in terms of CD4 ＋/CD8 ＋,CD8 ＋,CD4 ＋,and CD3 ＋,etc.The difference was statistically significant（ P〈0. 05）. Conclusions： The level of cellular immune function in patients with latent syphilis is low. The detection of peripheral blood T lymphocyte subpopulation for patients with latent syphilis has great significance in evaluating patients＇ therapeutic effect.
作者
吴满平
杨毅
WU Manping;YANG Yi(Tongxiang Dermatosis Prevention and Treatment Hospital, Jiaxing 314500, Zhejiang, China;Department of Dermatology, The First Hospital Affiliated to Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)
出处
《中国性科学》
2018年第4期133-135,共3页
Chinese Journal of Human Sexuality
关键词
临床观察
苄星青霉素G
T淋巴细胞亚群
隐性梅毒
Clinical observation
Benzathine Benzylpenicillin G
T lymphocyte subpopulation
Latent syphilis
