摘要
目的探讨我国肿瘤学临床研究论文中统计学方法应用方面存在的问题。方法在＂万方数据知识服务平台＂对我国肿瘤学期刊中的＂核心＂期刊进行检索，分析其2017年第1期发表的临床研究类论文中统计学方法应用方面存在的问题，包括统计学指标选择和方法选择、统计学结果解释等方面。结果24种期刊的共176篇临床研究类论文进入研究。在统计学指标的选择方面，12.6%（16篇）论文中对偏态分布的计量资料用了正态分布数据的表示方法；37.9%（47篇）论文中对样本数〈20的计数资料用百分比表示；14.5%（9篇）论文中存在以比代率问题。在统计学方法的选择方面，10.3%（12篇）论文多组间比较未先进行方差分析，而是直接使用t检验进行两两比较；15.1%（8篇）论文忽视χ2检验使用的前提条件错误套用。在统计结果的解释方面，18.4%（27篇）论文将统计学意义与生物学意义混淆。结论我国肿瘤学临床研究论文中普遍存在统计学问题，涉及从研究设计到结果解释的全过程，科研管理部门、临床研究工作者、期刊编辑需要共同努力，以提高我国肿瘤学临床科研成果的科学性。
ObjectiveTo investigate the application of statistical methods in clinical research articles of oncology in China.MethodsThe core journals in Chinese oncology journals were retrieved in ＂Wanfang Data＂, and the application of statistical methods in the clinical research articles published in the first issue of 2017 were analyzed, including the selection of statistical indicators, the selection of statistical methods and the interpretation of statistical results.ResultsA total of 176 clinical research articles from 24 journals were taken into the study. In the selection of statistical indicators, 12.6% （16 articles） used the description method of normal distribution data for the skewness distribution measurement data; 37.9% （47 articles） described the count data with samples 〈20 as a percentage; 14.5% （9 articles） replaced the constituent percentages with composition ratios. In the selection of statistical methods, 10.3% （12 articles） did not perform analysis of variance when comparing among multiple groups, and the t test was used to compare each other directly. 15.1% （8 articles） disregarded the preconditions of the use of the χ 2 test. In the interpretation of statistical results, 18.4% （27 articles） confused the statistical significance with biological significance.ConclusionsThe statistical problems are widespread in Chinese oncology clinical research articles, involving the entire process from study design to interpretation of results. Scientific research management departments, clinical researchers, and journal editorial board need to work together to improve the scientificity of clinical scientific research results of oncology in China.
作者
李旭清
郎华
张俊伟
陈磊
周薇
王妹雅
杨璐
冯莉
胡睿
Li Xuqing;Lang Hua;Zhang Junwei;Chen Lei;Zhou Wei;Wang Shuya;Yang Lu;Feng Li;Hu Rui(Department of Editorial Board, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China)
出处
《肿瘤研究与临床》
CAS
2018年第5期327-329,343,共4页
Cancer Research and Clinic
关键词
肿瘤学
临床研究
医学统计学
Oncology
Clinical studies
Medical statistics
