摘要
目的分析活络效灵汤联合瓜蒌薤白半夏汤对痰阻血瘀型冠状动脉粥样硬化性心脏病(冠心病)患者的凝血因子活性(R值)、纤维蛋白原水平(K值、Angle值)、血小板聚集功能(MA值)的影响。方法选取2016年1—12月在北京王府中西医结合医院的119例痰阻血瘀型冠心病患者,均常规服用阿司匹林肠溶片或硫酸氢氯吡格雷片。采用随机数字表法分为对照组A、观察组A、对照组B、观察组B。对照组A(29例)使用阿司匹林常规治疗,观察组A(30例)使用阿司匹林以及活络效灵汤联合瓜蒌薤白半夏汤治疗;对照组B(32例)使用硫酸氢氯吡格雷常规治疗,观察组B(28例)使用硫酸氢氯吡格雷以及活络效灵汤联合瓜蒌薤白半夏汤治疗。观察患者治疗后血浆血栓弹力图所测的R值、K值、Angle值、MA值等指标变化。结果观察组A、B所测的R值分别明显高于对照组A、B[(8.5±1.6)min比(5.1±1.7)min、(8.0±1.5)min比(6.0±0.6)min],MA值明显低于对照组A、B[(63.3±4.2)mm比(70.5±6.7)mm、(56.0±2.1)mm比(68.2±1.3)mm],差异均有统计学意义(均P<0.05)。2个观察组和对照组的K值、Angle值差异无统计学意义(P>0.05)。结论在服用抗血小板西药的基础上增加活络效灵汤联合瓜蒌薤白半夏汤可使痰阻血瘀型冠心病患者血浆中凝血因子活性、血小板聚集功能降低,对纤维蛋白原水平则无明显影响。
Objective To analyze the effect of Huoluo Xiaoling decoction combined with Gualou Xiebai Banxia decoction on coagulation factor activity（R value）, fibrinogen level（K value, Angle value） and platelet aggregation function（MA value） in patients with phlegm-obstruction and blood-stasis type coronary atherosclerotic heart disease（CHD）. Methods Totally 119 patients with phlegm-obstruction and blood-stasis type CHD from January to December 2016 in Beijing Royal Integrative Medicine Hospital were randomly divided into control group A, observation group A, control group B and observation group B. The control group A（n＝29） took aspirin; the observation group A（n＝30） took aspirin and Huoluo Xiaoling decoction combined with Gualou Xiebai Banxia decoction; the control group B（n＝32） took hydrogen clopidogel; the observation group B（n＝28） took hydrogen clopidogel and Huoluo Xiaoling decoction combined with Gualou Xiebai Banxia decoction. Thromboelastography was performed after treatment to determine R value, K value, Angle value and MA value. Results R value in observation group A（B） was significantly higher than that in control group A（B）［（8.5±1.6）min vs （5.1±1.7）min, （8.0±1.5）min vs （6.0±0.6）min］（P＜0.05）. MA value in observation group A（B） was significantly lower than that in control group A（B）［（63.3±4.2）mm vs （70.5±6.7）mm, （56.0±2.1）mm vs （68.2±1.3）mm］（P＜0.05）. K value and Angle value showed no significant differences between groups（P＞0.05）. Conclusion Huoluo Xiaoling decoction combined with Gualou Xiebai Banxia decoction can depress coagulation factor activity and platelet aggregation function in patients with phlegm-obstruction and blood-stasis type CHD.
作者
陈东
陈爱芳
张金荣
徐静
廖婧
Chen Dong;Chen Aifang;Zhang Jinrong;Xu ring;Liao Jing(Department of Cardiology, Beijing Royal Integrative Medicine Hospital, Beijing 102209, China;Department of Pharmacy, Beijing Royal Integrative Medicine Hospital, Beijing 102209, China)
出处
《中国医药》
2018年第6期818-821,共4页
China Medicine
关键词
冠状动脉粥样硬化性心脏病
活络效灵丹汤
瓜蒌薤白半夏汤
血栓弹力图
Coronary atherosclerotic heart disease
Huoluo Xiaoling decoction
Gualou Xiebai Banxiadecoction
Thromboelastography
