摘要
基肯孔雅病毒（The chikungunya virus,CHIKV）是近年来重新暴发的甲病毒,主要由埃及伊蚊叮咬传播,可引起基肯孔雅热。由于对该病毒的研究尚不完全,目前缺少针对性的预防和治疗方法。CHIKV具有全球暴发的可能性,是公众健康的潜在威胁。近期的研究已经发现许多CHIKV的宿主因子和限制性因子,本文通过总结这些因子,为今后进一步研究CHIKV与宿主细胞的相互作用以及探索其致病机制提供思路。
The chikungunya virus（CHIKV）has been a recurrent alphavirus in recent years.It is transmitted predominantly by bites from Aedes aegypti and can cause Chikungunya fever.Due to incomplete study of this virus,there is a lack of targeted prevention and treatment.As a potential public-health threat,a global outbreak of CHIKV is possible.Recent studies have revealed several host factors and restriction factors of the CHIKV.We summarize these factors and provide mechanistic insights for understanding the interaction between the CHIKV and host cells.
作者
殷瀚
张磊亮
YIN Han;ZHANG Leiliang(MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100176, China)
出处
《病毒学报》
CAS
CSCD
北大核心
2018年第3期430-435,共6页
Chinese Journal of Virology
基金
国家重点研发计划(项目号:2016YFD0500304).题目:病原感染与传播的实验模型及适应性进化与致病性、宿主嗜性研究~~
