摘要
目的探讨儿童Burkitt淋巴瘤患者血清IL-24及IL-6的含量及其临床意义。方法收集45例儿童Burkitt淋巴瘤患者外周血血清,ELISA法检测IL-24及IL-6的含量,分析血清IL-24及IL-6含量与患者临床指标之间的关系。结果发现Burkitt淋巴瘤患者血清IL-24含量明显低于正常对照组患者,而IL-6含量明显增高(P<0.01);同时血清IL-24及IL-6含量与肿瘤细胞侵犯骨髓状态及临床分期密切相关(P<0.01),而与患者年龄、性别及IPI指数均无明显相关(P>0.05)。结果儿童Burkitt淋巴瘤血清IL-24及IL-6含量与患者肿瘤骨髓侵犯及临床分期密切相关。结论血清IL-24及IL-6含量测定可作为Burkitt淋巴瘤的辅助诊断指标,为临床治疗提供科学依据。
To investigate the clinical values of serum IL-24 and IL-6 concentration in children patients with Burkitt lymphoma, we analyzed the association of serum IL-24 and IL-6 concentration with clinicopathological parameters in 45 cases of children patients with Burkitt lymphoma by using ELISA assays. Data showed that the IL-24 level in serum of patients with Burkitt lymphoma was significantly lower than that of patients in normal control groups（P〈0.01）. Both IL-24 and IL-6 levels in serum were associated with the bone marrow metastasis status and clinical stage of Burkitt lymphoma patients（P〈0.01）, while were not related to gender, age and the IPI index（P〈0.05）. These findings suggested that the concentration of IL-24 and IL-6 proteins in serum are closely correlated with the bone marrow metastasis status and clinical stage in children patients with Burkitt lymphoma.Thus, detection of the serum IL-24 and IL-6 concentration may provide the evidence for clinical therapy of Burkitt lymphoma as auxiliary diagnosis.
作者
马鸣
赵日旸
朱秀丽
杨兴肖
赵连梅
单保恩
MA Ming;ZHAO Riyang;ZHU Xiuli;YANG Xingxiao;ZHAO Lianmei;SHAN Bao＇ en(Department of Clinical Laboratory, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;Scientific Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;Department of Paediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;Department of Infectious Diseases Administration, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China)
出处
《免疫学杂志》
CAS
CSCD
北大核心
2018年第6期524-528,共5页
Immunological Journal
基金
河北省卫计委指令性课题(20160171)
