摘要
目的:探讨采用复方甘草酸苷治疗由利福平引发的药物性肝损伤的临床效果与作用机制。方法:对南京市胸科医院急诊内科于2017年1月-2017年6月收治的60例由利福平引起的药物性肝损伤患者,采用复方甘草酸苷注射液治疗,在患者用药前和用药1天后对外周血中谷丙转氨酶、谷草转氨酶、总胆红素、碱性磷酸酶、γ-谷氨酰转移酶的含量进行检测,同时对患者的治疗周期和治疗效果进行评估。数据以SPSS 20.0软件进行统计学分析,当P<0.05时,则认为数据间的差异具有统计学意义。结果:经过治疗后,患者外周血谷丙转氨酶、谷草转氨酶、总胆红素、碱性磷酸酶、γ-谷氨酰转移酶的水平明显低于治疗前,且数据间差异具有统计学意义。结论:复方甘草酸苷注射液能够有效改善由利福平引发的药物性肝损伤患者的临床指标并加快患者康复。
Objective： To explore the clinical effects and mechanisms of compound glycyrrhizin in the treatment of drug-induced liver injury by Rifampicin. Methods： Sixty patients with drug-induced liver injury by Rifampicin from the department of emergency of Nanjing thoracic hospital from January 2017 to June 2017 were treated with compound glycyrrhizin injection. The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood were measured before treatment and one day after treatment. Moreover, the treatment cycle and treatment effects were evaluated. The data were statistically analyzed by SPSS 20.0 software and the differences were considered statistically significant when P〈0.05. Results： The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood after treatment were significantly lower than those before treatment, and the differences between the data were statistically significant. Conclusion： Compound glycyrrhizin injection can effectively improve the clinical indexes of patients with drug-induced liver injury by Rifampicin and accelerate the rehabilitation.
作者
牛素梅
张驰
钱智磊
Niu Sumei;Zhang Chi;Qian Zhilei(Nanjing Thoracic Hospital, Nanjing 210029, China)
出处
《中国药事》
CAS
2018年第5期647-650,共4页
Chinese Pharmaceutical Affairs
关键词
复方甘草酸苷注射液
药物性肝损伤
临床评价
利福平
compound glycyrrhizin injection
drug-induced liver injury
clinical evaluation
Rifampicin
