摘要
目的探讨分析D2-40、CD34和单克隆抗体β-链蛋白(β-catenin)在ⅠA1期宫颈鳞癌组织中的表达及临床意义。方法选取医院就诊的ⅠA1期宫颈鳞癌患者65例进行分析,根据病理诊断进行分组,HE染色为对照组;免疫组化染色为观察组,采用D2-40、CD34及β-catenin进行标记,分析其与临床病理的关系。结果免疫组化染色阳性检出率明显著高于HE染色检出率(P<0.05)。对照组单克隆抗体β-catenin阳性3例(4.62%),CD34阳性1例(1.54%),D2-40阳性2例(3.08%);观察组单克隆抗体β-catenin阳性11例(16.92%),CD34阳性7例(10.77%),D2-40阳性8例(12.31%)。结论 D2-40、CD34及β-catenin检测在ⅠA1期宫颈鳞癌脉管浸润患者中可有效确诊疾病,术后复查阳性检出率确切,为临床预后提供有价值的信息。
Objective To investigate the expression and clinical significance of D2-40,CD34 and monoclonal antibody β-catenin in squamous cell carcinoma of stage ⅠA1. Methods Sixty-five patients with ⅠA stage 1 cervical squamous cell carcinoma at the selected hospital were analyzed and grouped according to the pathological diagnosis. HE staining was selected as the control group. Immunohistochemical staining was selected as the observation group. D2-40,CD34,and β-catenin were used for labeling and analysis of their relationship with clinicopathology. Results The positive rate of immunohistochemical staining was significantly higher than that of HE staining(P〈0. 05）. In the control group,there were 3 cases of positive β-catenin monoclonal antibody(4. 62%）,1 case of CD34 positive(1. 54%）,and 2 cases of D2-40 positive(3. 08%）. In the observation group,11 patients(16. 92%） were positive for β-catenin,7(10. 77%） were positive for CD34,and 8(12. 31%） were positive for D2-40. Conclusion Adopting D2-40,CD34 and β-catenin in treatment of stageⅠA1 cervical squamous cell carcinoma can effectively identify disease,make postoperative positive detection rate exact,which provides valuable information for clinical prognosis.
作者
陈燕
曹学锋
曾四元
CHEN Yan;CAO Xue-feng;ZENG Si-yuan(Jiujiang Maternal and child care centres , Jiujiang ,Jiangxi 332000, Chin)
出处
《临床合理用药杂志》
2018年第14期18-19,共2页
Chinese Journal of Clinical Rational Drug Use
基金
江西省卫生厅科技计划课题(No:20154036)
关键词
Β-链蛋白
宫颈癌筛查
宫颈鳞癌
β-catenin
Cervical cancer screening
Cervical squamous cell carcinoma
