摘要
报道1例诊断为慢性颌下腺炎的Ig G4-RD(Ig G4-related disease,Ig G4-RD)并复习相关文献。患者71岁,男,双侧颌下区包块。手术行双侧颌下腺切除术,病理报告:慢性颌下腺炎。术后3月,查ANA抗体(+),抗SSA(+),白球比0.7,血清Ig G5 350mg/L,病变组织有淋巴细胞和细胞浸润结合临床确诊为Ig G4-RD。给予糖皮质激素联合免疫抑制剂治疗3月,症状部分消失,部分缓解,免疫学指标趋正常。结合文献复习,Ig G4-RD常出现多个器官受累或相继受累症状,及时行血清Ig G4及病理学检查可减少漏诊。本病对糖皮质激素治疗反应良好,及时规范治疗可控制病情发展甚至治愈。
A case of IgG-related disease（IgG4-RD） is reported and the relevant literature is reviewed is this paper. A 71-year-old male patients underwent surgical treatment of bilateral submandibular gland resection for tumefaetion of the gland. Pathological examination showed chronic submandibular gland inflammation. 3 months after operation immunohistoehemical examination showed ana antibody （ ＋ ） , anti-SSA （ ＋ ）, baiqiubi 0.7, serum IgG 5, 350 mg/L and the infiltration of lymphocytes and cells in the pathological tissues. Clinical diagnosis of IgG 4-rd was then made. After treatment with glucoeorticoid combined with immunosuppressive therapy for 3 months no new pathological change was observed. Serum IgG and pathological examinations are recommended for the diagnosis of igG4-RD. Glucocorticoid treatment is effective for the treatment of the disease.
作者
史雨林
郭威孝
商洪涛
刘彦普
SHI Yulin;GUO Weixiao;SHANG Hongtao;LIU Yanpu(710032 Xi＇an, State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, China)
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2018年第3期421-423,共3页
Journal of Practical Stomatology
