摘要
目的:观察益气疏风通络方联合阿托伐他汀治疗2型糖尿病合并冠状动脉粥样硬化性心脏病的临床疗效。方法:70例2型糖尿病合并冠状动脉粥样硬化性心脏病患者随机分为对照组和观察组。对照组给予阿托伐他汀,观察组在对照组治疗基础上给予益气疏风通络方。比较两组患者的临床疗效,生存质量评分,血清血管抑素(angiostatin,AS)、内皮抑素(endostatin,ES)水平,中医证候积分及不良反应情况。结果:治疗前两组患者血清AS、ES、中医证候积分、生存质量评分比较,差异均无统计学意义(P>0.05);治疗后两组患者血清AS、ES、中医证候积分均明显下降,差异具有统计学意义(P<0.05);观察组治疗后以上指标均明显低于对照组治疗后,差异具有统计学意义(P<0.05);与治疗前比较,治疗后两组患者生存质量评分均明显上升,差异有统计学意义(P<0.05),且观察组明显高于对照组,差异具有统计学意义(P<0.05)。观察组有效率为94.29%,对照组有效率为74.29%,两组比较,差异具有统计学意义(P<0.05);观察组的不良反应发生率为5.71%,对照组为20.00%,两组比较,差异有统计学意义(P<0.05)。结论:益气疏风通络方联合阿托伐他汀治疗2型糖尿病合并冠状动脉粥样硬化性心脏病疗效确切,可有效降低患者血清AS、ES水平,减少不良反应的发生。
Objective： To observe the clinical effect of Yiqi Shufeng Tongluo prescrption combined with atorvastatin on type 2 diabetes mellitus with coronary heart disease. Methods： 70 cases of patients were randomly divided into the control group and the observation group. The control group was given atorvastatin,and the observation was treated by Yiqi Shufeng Tongluo prescrption combined with atorvastatin. The clinical efficacy,quality of life(QOL）,serum angiostatin(AS）,endostatin(ES） levels,TCM syndrome scores and adverse reactions were compared between the two groups. Results： Before the treatment,compared the serum AS and ES,TCM score and grade of quality of life of the two groups,there was no statistical significance(P 〉 0. 05）. After treatment,the serum AS,ES and TCM score were significantly decreased,there was statistical significance(P 〈 0. 05）. After treatment,the above indexes in the observation group was significantly lower than the control group,there was statistical significance(P 〈 0. 05）.Compared with before treatment,the grade of quality of life of the two groups was significantly increased,there was statistical significance(P 〈 0. 05）,and the observation group was significantly higher than the control group,the difference was statistically significant(P 〈 0. 05）. The effective rate of the observation group was 94. 29%,that was significantly higher than 74. 29% of the control group,there was statistical significance(P 〈 0. 05）. The incidence of adverse reactions was 5. 71% in the observation group and 20. 00% in the control group(P 〈 0. 05）. Conclusion： Yiqi Shufeng Tongluo prescription combined with atorvastatin is effective in treating type 2 diabetes mellitus with coronary heart disease,which can effectively reduce the level of serum AS and ES,decrease the occurrence of adverse reactions.
作者
刘中华
王昃睿
王晓东
LIU Zhonghua;WANG Zerui;WANG Xiaodong(Xiangyang Chinese Medicine Hospital,Xiangyang Hubei China 441000)
出处
《中医学报》
CAS
2018年第5期751-755,共5页
Acta Chinese Medicine
基金
湖北省卫生厅科研基金项目(JX2873)
关键词
益气疏风通络方
阿托伐他汀
2型糖尿病合并冠状动脉粥样硬化性心脏病
血管抑素
内皮抑素
中西医结合
iqi Shufeng Tongluo prescription
atorvastatin
type 2 diabetes mellitus with coronary heart disease
angiostatin
endostatin
combination of traditional Chinese and western medicine
