摘要
内皮间质转化(endothelial-mesenchymal transition,EndMT)是指在多项影响因素的作用下,内皮细胞的结构和功能向间质细胞转变。研究显示在内皮的功能调节、心肌细胞、血管及心脏瓣膜等的发育和结构重塑等方面都有EndMT参与,表明心血管疾病领域在该方面投入更多研究的意义逐渐凸显。了解EndMT过程中信号转导通路,有助于进一步认识EndMT引起心肌纤维化(myocardial fibrosis,MF)的机制,为探索干预MF的治疗方案提供更多依据。
Endothelial-mesenchymal transition （EndMT） results from the induction of some transcription factors, leading to a shift in cytoskeletal dynamics and a change of morphology and physiology from epithelial to the mesenchymal phenotype. Previous studies in recent years showed that EndMT participates in endothelial function regulation, development and remodeling of myocardial cells, vascular and heart valves, which indicates the essence of research on EndMT in cardiovascular diseases. Therefore, to understand the mechanisms and signal pathways of EndMT may provide therapeutic strategies and perspective for treating the diseases.
作者
曲嘉琛
袁也
唐俊明
王家宁
QU Jiachen;YUAN Ye;TANG Junming;WANG Jia＇ning(Institute of Clinical Medicine, People＇s Hospital;Department of Physiology, School of Basic Medical Science;Center qf Cardiology, People＇s Hospital, Hubei University of Medicine, Shiyan Hubei 442000, China)
出处
《临床与病理杂志》
2018年第4期892-896,共5页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81270221
81670272)
湖北医药学院创新团队项目(FDFR201601)~~
关键词
内皮间质转化
心肌纤维化
信号转导通路
endothelial-mesenchymal transition
myocardial fibrosis
signal pathways
