摘要
目的探讨宫颈癌组织中CC族趋化因子受体7(CCR7)、血管内皮生长因子-D(VEGF-D)的表达水平及其与临床病理参数的关系,旨在为临床治疗宫颈癌提供新的靶点。方法选取2015年7月-2016年11月该院妇产科收治,并行宫颈根治性切除手术标本93例为观察组;另选取同期疑似宫颈癌患者62例为对照组。应用免疫组化SP法检测CCR7和VEGF-D的阳性表达情况。对宫颈癌组织中CCR7和VEGF-D的阳性表达情况进行相关性分析。结果观察组CCR7和VEGF-D阳性表达水平明显高于对照组(P<0.05)。宫颈癌组织中CCR7的阳性表达情况与患者的年龄、癌变类型、浸润深度、绝经状况、宫旁浸润无关(P>0.05),与宫颈癌分期、组织分化程度、肿瘤直径、淋巴结转移及阴道浸润有关(P<0.05)。宫颈癌组织中VEGF-D的阳性表达情况与患者的年龄、癌变类型、宫颈癌分期、肿瘤直径、绝经状况、宫旁浸润及阴道浸润无关(P>0.05),与组织分化程度、浸润深度及淋巴结转移有关(P<0.05);CCR7的阳性表达与VEGF-D的阳性表达呈正相关(r=0.732,P=0.025)。结论 CCR7和VEGF-D在宫颈癌组织中阳性表达率升高,与宫颈癌的发生发展过程联系紧密,能够作为临床治疗宫颈癌的新靶点。
Objective To explore the expression levels of CXC chemokine receptor 7(CCR7） and vascular endothelial growth factorD(VEGF-D） in cervical cancer tissue and the relationships with clinicopathological parameters,provide new target for clinical treatment of cervical cancer. Methods From July 2015 to November 2016,93 patients undergoing cervical radical resection surgery in Department of Gynecology and Obstetrics in Shekou People’s Hospital of Shenzhen were selected as observation group,and 62 patients suspected of cervical cancer were selected as control group. Immunohistochemical SP method was used to detect the positive expressions of CCR7 and VEGF-D.The correlation of positive expressions of CCR7 and VEGF-D was analyzed in cervical cancer patients. Results The positive expression levels of CCR7 and VEGF-D in observation group were statistically significantly higher than those in control group(P〈 0. 05）. The positive expression of CCR7 in cervical cancer was not correlated with age,tumor type,infiltration depth,menopause,and parauterine invasion(P〉0. 05）,but it was correlated with cervical cancer staging,the degree of differentiation,tumor diameter,lymph node metastasis,and vaginal invasion(P〈0. 05）. The positive expression of VEGF-D in cervical cancer was not correlated with age,tumor type,cervical cancer staging,tumor diameter,menopause,parauterine invasion,and vaginal invasion P〉0. 05）,but it was correlated with the degree of differentiation,infiltration depth,and lymph node metastasis(P〈0. 05）. The positive expression of CCR7 was positively correlated with the positive expression of VEGF-D(r = 0. 732,P = 0. 025）. Conclusion The positive expression rates of CCR7 and VEGF-D in cervical cancer increase,and they are closely associated with the oncogenesis and aggravation of cervical cancer,which can be used as new targets in clinical treatment of cervical cancer.
作者
黄树峰
朱艳宾
武艳玲
陈玉阁
庄严
HUANG Shu-Feng;ZHU Yan-Bin;WU Yan-Ling(Department of Gynecology and Obstetrics, Shekou People＇s Hospital of Shenzhen, Shenzhen, Guangdong 518000, China)
出处
《中国妇幼保健》
CAS
2018年第9期1928-1931,共4页
Maternal and Child Health Care of China
基金
深圳市科技计划项目(JCYJ20150403093555011)
