摘要
目的:探讨血清IL-26和高迁移率族蛋白1(HMGB1)与急性带状疱疹疼痛(AHP)和后遗神经痛(PHN)之间的关系。方法:ELISA方法检测带状疱疹患者57例(AHP 40例,PHN17例)和健康对照组30例血清中IL-26、HMGB1的水平。结果:AHP组和PHN组IL-26平均水平分别为(15.97±2.48)pg/m L、(13.90±3.86)pg/m L,高于对照组的(8.00±0.38)pg/m L,有统计学差异(P<0.05);PHN组HMGB1平均水平为(7.91±9.29)ng/m L,明显高于AHP组(3.80±6.30)ng/m L和健康对照组(4.03±5.45)ng/m L(P<0.05)。AHP组中疼痛VAS评分与血清IL-26浓度有相关性(r=-0.435,P<0.05),与HMGB1无相关性(r=0.109,P>0.05)。PHN组中疼痛VAS评分与IL-26和HMGB1水平均无相关性(P>0.05)。结论:IL-26可能与AHP的发病机制有关。
Objective： To determine the correlation between serum IL-26,high mobility group box-1 protein(HMGB1） and acute herpes zoster pain(AHP） or posterior neuralgia(PHN）. Methods： The expression levels of IL-26 and HMGB1 were detected by ELISA in 57 patients with herpes zoster(40 cases of AHP,17 cases of PHN） and 30 healthy controls. Results： The average levels of IL-26 in the AHP group and PHN group were(15.97±2.48） pg/m L and(13. 90 ± 3. 86） pg/m L,which were higher than that in control group(8.00±0.38） pg/m L,with a significant difference(P〈0.05）. The average level of HMGB1 in PHN group was(7.91±9.29） ng/m L,which was higher than those in AHP group(3.80±6.30） ng/m L and control group(4.03±5.45） ng/m L,with significant differences(P〈0.05）. In AHP group,there was a correlation between VAS score and the level of serum IL-26(r =-0.435,P〈 0.05）. In the PHN group,there was no correlation between VAS score and the level of serum IL-26 or HMGB1. Conclusion： IL-26 may be involved in the pathogenesis of AHP.
作者
李蜜
张怡萱
刘莉萍
李遇梅
LI Mi;ZHANG Yixuan;LIU Liping;LI Yumei(Department of Dermatology, Affiliated Hospital of Jiangsu University, Regenerative Medicine Center, Jiangsu University, Zhenjiang 212001, Jiangsu, China)
出处
《中国麻风皮肤病杂志》
2018年第4期222-225,共4页
China Journal of Leprosy and Skin Diseases
基金
镇江市科技计划资助项目(编号:SS2015024)
2015年国家自然科学基金面上项目(编号:81573053)
2015江苏省"333工程"培养资金资助项目(编号:BRA2015196)
