摘要
目的 探讨呼出气一氧化氮（ＦｅＮＯ）水平检测应用于临床支气管哮喘患者治疗中的作用，并观察ＦｅＮＯ水平与患者肺功能的相关性。方法 回顾性分析６１例急性加重期支气管哮喘患者临床资料，纳入病例组；根据患者病情程度分为轻度哮喘组３０例、中度哮喘组３１例。另选取同期６０例健康人群作为对照组。所有患者均给予相应的对症治疗，并分别于治疗前、后检测病例组与对照组ＦｅＮＯ及肺功能情况。结果轻度哮喘组患者治疗后ＦｅＮＯ水平为（２２．２２±８．３９）ｐｐｂ，明显低于中度哮喘组的（３５．２１±１０．８４）ｐｐｂ（ｔ＝５２２，Ｐ＝０．００）；轻度哮喘组患者治疗后ＦＥＶ１、ＰＥＦ分别为（２．４９±０．３８）％、（３．８２±０．２４）Ｌ／ｍｉｎ，中度哮喘组分别为（２．５２±０．４１）％、（３．７４±０．３５）Ｌ／ｍｉｎ，两组差异均无统计学意义（ｔ＝０．２９、１．０３，Ｐ＝０．７６、０．３０）；两组治疗后ＦｅＮＯ水平明显低于治疗前，而ＦＥＶ１、ＰＥＦ水平明显高于治疗前（均Ｐ＜００５）。病例组治疗前
ＦｅＮＯ、ＦＥＶ１、ＰＥＦ水平分别为（５０．４１±３０．０９）ｐｐｂ、（１．９８±０．３７）％、（３．２４±０．３６）Ｌ／ｍｉｎ，对照组分别为（１２５９±６．３９）ｐｐｂ、（２．７９±０．３４）％、（４．０２±０．１８）Ｌ／ｍｉｎ，两组差异均有统计学意义（ｔ＝９．５２、１２．５３、１５．０３，Ｐ＝０．００、０．００、０．００）；病例组治疗后ＦｅＮＯ、ＦＥＶ１、ＰＥＦ水平分别为（２３．５２±１０．５４）ｐｐｂ、（２．８１±０．３５）％、（３９１±０．４０）Ｌ／ｍｉｎ，对照组分别为（１２．�
Objective To investigate the role of exhaled nitric oxide （FeNO） detection in patients with bron- chial asthma,and to observe the correlation between FeNO level and pulmonary function. Methods The clinical data of 61 patients with acute exacerbation of bronchial asthma were retrospectively analyzed. The patients were included in the case group. According to the disease condition, the patients were divided into mild asthma group （30 cases） and moderate asthma group （31 cases）. A total of 60 healthy people were selected as the control group. All the patients were given corresponding symptomatic treatment, before and after treatment, the FeNO and lung function were deter- mined in two groups. Results After treatment, the level of FeNO in the mild asthma group was （22.22 ± 8.39） ppb, which was significandy lower than （35.21 ± 10.84 ）ppb in the moderate asthma group （t = 5.22, P = O. 00）. The levels of FEV1 and PEF in the mild asthma group were （2.49 ± 0. 38 ） %, （3.82 ± 0. 24） L/min, respectively, which in the moderate asthma group were （2.52 ± 0.41 ） %, （ 3.74 ± 0.35 ） L/min, respectively, the differences between the two groups were not statistically significant （t = 0.29,1.03,P = 0.76,0.30）. The FeNO levels of the two groups after treatment were significantly lower than those before treatment, and the FEV1 , PEF levels were significantly higher than those before treatment （all P 〈 0. 05 ）. Before treatment, the levels of FeNO, FEV and PEF in the case group were（50.41 ± 30.09 ） ppb, （ 1.98 ± 0. 37 ） %, （ 3.24 ± 0.36 ） L/min, respectively, which in the control group were （ 12.59 ± 6.39 ） ppb, （ 2.79 ± 0.34 ） %, （ 4.02 ± 0.18 ） L/rain, respectively, the differences were statistically signifi- cant between the two groups （ t = 9.52,12.53,15.03, P = 0.00,0.00,0.00）. After treatment, the levels of FeNO, FEV1 and PEF in the case group were （23.52 ±10. 54）ppb,（2.81 ±0.35）% ,（31 91 ±0.40） L/min,respeetively, which in the
作者
陈优琴
Chen Youqin(Department of Respiratory Medicine, Taizhou Branch of Zhejiang Provincial Tumor Hospital, Taizhou ,Zhejiang 317502, China)
出处
《中国基层医药》
CAS
2018年第10期1329-1333,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
哮喘
一氧化氮
呼气
呼吸功能试验
Asthma
Nitric oxide
Exhalation
Respiratory function tests
