摘要
目的探讨不同初始剂量艾司西酞普兰治疗抑郁症伴主观性头晕的临床疗效。方法选取2015年1月-2016年10月某院收治的120例抑郁症伴主观性头晕患者为对象,依据治疗方法不同将其分为低剂量组、中剂量组、高剂量组,治疗前、治疗后2周、4周、6周采用汉密尔顿抑郁量表(HAMD)评估两组患者抑郁症状,观察治疗后两组临床疗效、眩晕残障程度评定量表(DHI)及药物安全性。结果治疗前3组HAMD评分、DHI评分相较无明显差异(P>0.05);与治疗前相较,治疗后2周、4周、6周3组HAMD评分、DHI评分明显降低,并且治疗后中剂量组降低幅度最为明显(P<0.05),而低剂量组和高剂量组相较无明显差异(P>0.05);治疗后中剂量组总有效率较高剂量组和低剂量组明显高,差异有统计学意义(P<0.05),而低剂量组和高剂量组总有效率相较无明显差异(P>0.05);治疗后3组药物不良反应发生率相较无明显差异(P>0.05)。结论艾司西酞普兰治疗抑郁症伴主观性头晕患者的初始剂量设为10mg/次/天,其改善患者临床抑郁症状、头晕相关症状更为显著,是一种疗效佳、安全性高的给药方案。
Objective To investigate the clinical efficacy of different initial doses of escitalopram in the treatment of depression with subjective dizziness. Methods 120 patients with depression and subjective dizziness treated in the hospital from January 2015 to October 2016 were selected as study subjects. According to different treatment methods, the patients were divided into the low dose group, the middle dose group and the high dose group. The depressive symptoms in two groups were evaluated with the Hamilton Depression Scale before treatment, and at 2, 4 and 6 weeks after treatment. The clinical curative effect, Dizziness Handicap Inventory（DHI） and drug safety were observed before and after treatment. Results There was no significant difference among the three groups in the HAMD score and DHI score（P〉0.05）. HAMD scores and DHI scores were significantly decreased in the threegroups at 2, 4 and 6 weeks after treatment, and the decrease in middle dose group was the most obvious（P〈0.05） but there was no significant difference between the low dose group and high dose group（P〉0.05）. After treatment, the total effective rate of the middle dose group was higher than that of the high dose group or the low dose group（P〈0.05）but there was no significant difference between the low dose group and high dose group（P〉0.05）. There was no significant difference in the incidence of adverse drug reactions among the three groups after treatment（P〉0.05）.Conclusions The application of escitalopram in the treatment of depression with dizziness with an initial dose of 10 mg/times per day could more obviously relieve related symptoms of depression and dizziness. It was an effective and safe administration regimen.
作者
高永双
Gao Yongshuang(The Third People＇s Hospital in Zhongshan City, Zhongshan 528451, Chin)
出处
《中国病案》
2018年第5期106-109,共4页
Chinese Medical Record
