摘要
微小核糖核酸(microRNAs,miRNAs)是一类非编码小分子RNA,主要在转录后水平调节基因的表达,进而在功能上通过调控下游基因的表达来影响组织和细胞的生物学功能。目前研究已证实miRNAs的异常表达与肿瘤的发生发展密切相关。本文对近年发现致肝细胞癌的miRNAs相关研究进展进行综述。
MicroRNAs（miRNAs）are small,noncoding RNAs that play an important role in posttranscriptional gene regulation and function as negative regulators. Deregulated miRNAs can contribute to the development of carcinoma. This review discusses the new data available on hepatocellular carcinoma associated with miRNAs.
作者
那延立
张城硕
张佳林
NA Yanli;ZHANG Chengshuo;ZHANG Jialin(Department of General Surgery,Northeast International Hospital,Shenyang 110623,China.;Department of Hepatobiliary Surgery and OrganTransplantation,The First Affiliated Hospital of China Medical University)
出处
《沈阳医学院学报》
2018年第3期193-196,203,共5页
Journal of Shenyang Medical College
基金
辽宁省自然科学基金项目(No.201602874)
