摘要
过氧化物还原酶6(peroxiredoxin 6,Prdx6)是过氧化物还原酶家族的第6个成员,具有不同于传统Prdxs家族成员的结构特点。Prdx6除了具有清除氧自由基、抗氧化应激的功能外,越来越多的研究表明该蛋白在中枢神经系统疾病中可以发挥多种作用。因此,本文就Prdx6的结构和活性特点,对该蛋白在中枢神经系统疾病中的研究现状进行总结和评述。
Peroxiredoxin 6（Prdx6） is the sixth member of peroxidases family with a unique structure from the other members. Besides the mechanisms of eliminating oxygen free radicals and anti-oxidative stress,more and more studies have revealed that Prdx6 plays a variety of roles in central nervous system diseases. Therefore,in this review,we will summarize and comment on the recent research progress of Prdx6 in central nervous system diseases based on its structure and activity characteristics.
作者
唐建巍
肖广庆
陈慧珍
李爱民
TANG Jianwei;XIAO Guangqing;CHEN Huizhen;LI Aimin(Department of Neurosurgery, Xuzhou Medical Affiliated Hospital Of Lianyungang, Lianyungang Jiangsu, China, 222000;Neuroscience Institute, Xuzhou Medical Affiliated Hospital Of Lianyungang Lianyungang, Jiangsu, China, 222000)
出处
《分子诊断与治疗杂志》
2018年第3期212-216,共5页
Journal of Molecular Diagnostics and Therapy
基金
江苏省科技厅基金资助项目(BE2015675)
